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Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice


Kovarik, Zrinka; Čalić, Maja; Lucić Vrdoljak, Ana; Radić, Božica
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice // Journal of molecular neuroscience, 30 (2006), 1/2; 113-114 doi:10.1385/JMN:30:1:113 (međunarodna recenzija, članak, znanstveni)


Naslov
Interaction of pyridinium oximes with acetylcholinesterase and their effect on organophosphate-poisoned mice

Autori
Kovarik, Zrinka ; Čalić, Maja ; Lucić Vrdoljak, Ana ; Radić, Božica

Izvornik
Journal of molecular neuroscience (0895-8696) 30 (2006), 1/2; 113-114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acetylcholinesterase; antidote; nerve agent; inhibition; reactivation; oxime; antidotal treatment

Sažetak
The progresive inhibition of acetylcholinesterase (AChE, EC3.1.1.7)by organophosphates (OPs), such as nerve agents tabun and soman, is due to phosphorylation of the active center serine characterized by the formation of conjugates and inactivation of this essential enzyme involved in neurotransmission. We investigated the interactions of five bispyridinium oximes with human erythrocyte AChE and their effects on tabun-and soman-poisoned mice.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0022014
0022015

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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