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Bovine platelet-activating factor acetylhydrolase (PAF-AH) activity related to fertility


Turk, Romana; Juretić, Dubravka; Gereš, Darko; Bačić, Goran; Milešević, Mario; Flegar-Meštrić, Zlata; Turk, Nenad; Svetina, Ante
Bovine platelet-activating factor acetylhydrolase (PAF-AH) activity related to fertility // Animal Reproduction Science, 105 (2008), 3/4; 344-353 doi:10.1016/j.anireprosci.2007.03.016 (međunarodna recenzija, članak, znanstveni)


Naslov
Bovine platelet-activating factor acetylhydrolase (PAF-AH) activity related to fertility

Autori
Turk, Romana ; Juretić, Dubravka ; Gereš, Darko ; Bačić, Goran ; Milešević, Mario ; Flegar-Meštrić, Zlata ; Turk, Nenad ; Svetina, Ante

Izvornik
Animal Reproduction Science (0378-4320) 105 (2008), 3/4; 344-353

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PAF-AH; dairy cows; fertility; CRP

Sažetak
Plasma platelet-activating factor acetylhydrolase (PAF-AH), the enzyme characterized by the association with plasma lipoproteins, degrades platelet-activating factor (PAF) as well as PAF-like oxidatively fragmented phospholipids produced during oxidative stress. Apart from pro-inflammatory properties, PAF is also related to reproductive processes and successful fertility. In order to get a better insight into the involvement of PAF-AH in the fertility of cows, the aim of the study was to determine the PAF-AH activity as well as the C-reactive protein, cholesterol and high density lipoprotein-cholesterol (HDL-C) in the serum of dairy cows throughout the pregnancy and lactation, as well as in infertile cows. The results showed that serum PAF-AH activity changes throughout pregnancy and lactation with a lower level during periparturient period. It is also found higher PAF-AH activity in lactating cows with reproductive disorders compared to high lactating cows without reproductive disorders. Strong correlation between PAF-AH activity and HDL-C concentration indicates that HDL could have considerable influence on PAF-AH activity in bovine plasma. CRP concentration was also lower during transition period suggesting that lactation might stimulate CRP synthesis in bovine. A higher CRP concentration in cows with reproductive disorders compared to fertile cows at the peak of lactation, demonstrates that milk production is not the only factor influencing CRP in cows. A significant correlation between PAF-AH activity and CRP level shows that both parameters could be influenced by reproductive status of dairy cows.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Projekt / tema
006-0061117-1236 - Posttranskripcijsko utišavanje stresnih proteina pomoću siRNA nanoterapije (Karmela Barišić, )
044-0061245-0551 - Novi biokemijski biljezi ateroskleroze u krvožilnim bolestima (Zlata Flegar-Meštrić, )
053-0532052-2046 - Smanjena plodnost u mliječnih goveda (Darko Gereš, )
053-1430115-2116 - Molekularna epizootiologija i epidemiologija leptospiroze (Nenad Turk, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinička bolnica "Merkur",
Veterinarski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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