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CSF tau proteins in evaluation of patients with suspected dementia


Šimić, Goran; Boban, Marina; Šarac, Helena; Grbić, Kristina; Hof, Patrick; Hamann, Christine; Ackl, Nibal; Bader, Benedikt; Danek, Adrian
CSF tau proteins in evaluation of patients with suspected dementia // Neurodegenerative Diseases Vol. 4 (Suppl. 1). 8th International Conference AD/PD Alzheimer's and Parkinson's Diseases: Progress and New Perspectives : Abstracts / Fisher, A ; Hanin, I ; Poewe W ; Windisch, M (ur.).
Basel: Karger, 2007. str. 135-136 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
CSF tau proteins in evaluation of patients with suspected dementia

Autori
Šimić, Goran ; Boban, Marina ; Šarac, Helena ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Bader, Benedikt ; Danek, Adrian

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurodegenerative Diseases Vol. 4 (Suppl. 1). 8th International Conference AD/PD Alzheimer's and Parkinson's Diseases: Progress and New Perspectives : Abstracts / Fisher, A ; Hanin, I ; Poewe W ; Windisch, M - Basel : Karger, 2007, 135-136

ISBN
3-8055-8282-7

Skup
8th International Conference AD/PD Alzheimer's and Parkinson's Diseases: Progress and New Perspectives

Mjesto i datum
Salzburg, Austrija, 14-18.03.2007.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease; cerebrospinal fluid; early diagnosis; tau proteins; frontotemporal dementia; vascular dementia; Lewy-body disease; Creutzfeld-Jacob disease

Sažetak
We tried to evaluate the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early-onset Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD), diffuse Lewy-body disease (DLBD) and Creutzfeld-Jacob disease (CJD). CSF levels were measured using commercially available ELISA kits (t-tau and p-tau199 - BioSource, Camarillo, CA, USA and p-tau181 - Innogenetics, Ghent, Belgium). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. P-tau181 showed best sensitivity and specificity for AD vs DLB (sens. 91%, spec. 94%), t-tau for AD vs VaD (sens. 91%, spec. 95%), while p-tau199 showed low specificity (25-30% when sensitivity was set at 85% or greater). We concluded that total tau and p-tau181 represent useful biological markers for distinguishing AD from other primary causes of dementia, suggesting that CSF examination of tau proteins should become a part of routine diagnostic procedure for patients with suspected dementia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

Napomena
Sažetak rada je tiskan u časopisu Neurodegenerative Diseases 2007 Vol. 4 (Suppl. 1): 135-136. Ovaj časopis se redovito indeksira u Current Contents i Index Medicus/Medline, a sam članak je indeksiran u Science Citation Index expanded.



POVEZANOST RADA


Projekt / tema
108-1081870-1942 - Fosforilacija tau proteina u razvitku i Alzheimerovoj bolesti (Goran Šimić, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE