engleski

CSF tau proteins in evaluation of patients with suspected dementia

We tried to evaluate the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181 and serine 199 (p-tau181 and p-tau199) in early-onset Alzheimer's disease (AD) versus healthy controls (HC) and other primary causes of dementia, such as frontotemporal dementia (FTD), vascular dementia (VaD), diffuse Lewy-body disease (DLBD) and Creutzfeld-Jacob disease (CJD). CSF levels were measured using commercially available ELISA kits (t-tau and p-tau199 - BioSource, Camarillo, CA, USA and p-tau181 - Innogenetics, Ghent, Belgium). Mean CSF t-tau and CSF p-tau181 levels were significantly elevated in AD patients compared to FTD, VaD and HC. P-tau181 showed best sensitivity and specificity for AD vs DLB (sens. 91%, spec. 94%), t-tau for AD vs VaD (sens. 91%, spec. 95%), while p-tau199 showed low specificity (25-30% when sensitivity was set at 85% or greater). We concluded that total tau and p-tau181 represent useful biological markers for distinguishing AD from other primary causes of dementia, suggesting that CSF examination of tau proteins should become a part of routine diagnostic procedure for patients with suspected dementia.

Alzheimer's disease; cerebrospinal fluid; early diagnosis; tau proteins; frontotemporal dementia; vascular dementia; Lewy-body disease; Creutzfeld-Jacob disease

Sažetak rada je tiskan u časopisu Neurodegenerative Diseases 2007 Vol. 4 (Suppl. 1): 135-136. Ovaj časopis se redovito indeksira u Current Contents i Index Medicus/Medline, a sam članak je indeksiran u Science Citation Index expanded.