engleski

Enantiomers of Sterically Hindered N-aril-4-Pyridones. Cromatographic Enrichment and Thermal Interconversion

N-Aryl-4-pyridones l-6 were synthesized by condensation of the corresponding 4-pyrone with anilines. The enrichment of the enantiomers was achieved by liquid chromatography on triacetylcellulose, enantiomeric purities of ( +)– l and (+)– 2 being measured by 1H NMR in the presence of an optically active auxiliary. Barriers to partial rotation about the C- N bond in l-4 were determined and compared with corresponding biphenyls.

enantiomers; sterically hindered N-aril-4-pyridones

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