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Pregled bibliografske jedinice broj: 296349

Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance


Brozović, Anamaria; Osmak, Maja
Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance // Cancer letters, 251 (2007), 1; 1-16 doi:10.1016/j.canlet.2006.10.007 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance

Autori
Brozović, Anamaria ; Osmak, Maja

Izvornik
Cancer letters (0304-3835) 251 (2007), 1; 1-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
MAPK ; cisplatin ; drug resistance

Sažetak
Mitogen-activated protein kinases (MAPKs) are critical components of a complex intracellular signalling network that ultimately regulates gene expression in response to a variety of extracellular stimuli. By transducing the signals from the cell surface to the nucleus and activating there gene expression, MAPKs control cell proliferation, differentiation and cell death. In mammalian cells there are three major pathways of MAPKs: stress-activated protein kinase/c-Jun-N-terminal kinase (SAPK/JNK), p38 kinase and extracellular regulated kinase (ERK). Generally, SAPK/JNK and p38 are key mediators of stress and inflammation responses evoked by a variety of physical, chemical and biological stress stimuli, while ERK 1/2 cascade is mostly induced by growth factors. The importance of MAPKs activation in cell response to cis-diamminedichloroplatinum(II) (cisplatin ; cDDP) and resistance development to this anti-cancer drug has been gradually appreciated in recent years. Today it is believed that MAPK activation is a major component deciding the fate of the cell in response to cisplatin. Their role in response to cisplatin is complex as they are, in most cases, able to induce apoptosis, but also suppress it or have no role in this process, depending on cell type, and proliferation and differentiation status of tumour cells. This review summarises current knowledge concerning the role of MAPK family members in cell response to cDDP, as well as their role in cisplatin-resistance.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Maja Osmak, )
098-0982913-2850 - Povećanje transdukcije adenovirusnih vektora i otpornost stanica na citostatike (Andreja Ambriović Ristov, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Osmak (autor)

Avatar Url Anamaria Brozović (autor)

Citiraj ovu publikaciju

Brozović, Anamaria; Osmak, Maja
Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance // Cancer letters, 251 (2007), 1; 1-16 doi:10.1016/j.canlet.2006.10.007 (međunarodna recenzija, pregledni rad, znanstveni)
Brozović, A. & Osmak, M. (2007) Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance. Cancer letters, 251 (1), 1-16 doi:10.1016/j.canlet.2006.10.007.
@article{article, year = {2007}, pages = {1-16}, DOI = {10.1016/j.canlet.2006.10.007}, keywords = {MAPK, cisplatin, drug resistance}, journal = {Cancer letters}, doi = {10.1016/j.canlet.2006.10.007}, volume = {251}, number = {1}, issn = {0304-3835}, title = {Activation of mitogen-activated protein kinases by cisplatin and their role in cisplatin-resistance}, keyword = {MAPK, cisplatin, drug resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts
  • BIOSIS
  • EMBASE
  • Oncology Information Service
  • Pascal et Francis (INST-CNRS)


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