engleski

Sterically Hindered N-Aryl-2(1H)quinolones and N-Aryl-6-(5H)phenanthridinones: Separation of Enantiomers and Barriers to Racemization

As a consequence of restrected rotation about the C-N bond the groun state of N-aryl-2(lH)-quinolones l-4, N-aryl-2-quinolono /4, 3-c/-2-pyrone 5 and N-aryl-6(5H).phenantridinones 6-7 is nonplanar, i.e. chiral. Separation or enrichment of enantiomers (M) and (P) of l-7 was achieved by liquid chromatography on optically active triacetylcellulose. The barriers to partial rotation about the C-N bond in 1-4, 6 and 7 were determined by thermal racemization of enantiomers and compared with those of structurally related molecules.

separation of enantiomers; quinolones; phenantridinones

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