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Pregled bibliografske jedinice broj: 295821

Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles


Starčević, Kristina; Kralj, Marijeta; Ester, Katja; Sabol, Ivan; Grce, Magdalena; Pavelić, Krešimir; Karminski-Zamola, Grace
Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles // Bioorganic & medicinal chemistry, 15 (2007), 13; 4419-4426 doi:10.1016/j.bmc.2007.04.032 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles

Autori
Starčević, Kristina ; Kralj, Marijeta ; Ester, Katja ; Sabol, Ivan ; Grce, Magdalena ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 15 (2007), 13; 4419-4426

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Benzimidazoles; amidines; N-methylpyrrole; pyridine; imidazole; antiviral activity; antitumor activity

Sažetak
We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Interestingly, all compounds show remarkable selectivity towards breast cancer cell line MCF-7. The most distinct and selective antiviral activity towards Coxackieviruses and Echoviruses was observed with compounds having pyridine ring at C-2. Especially interesting was fairly strong activity of the compounds 4 and 8 toward adenoviruses, which could be considered as leads against adenoviral replication.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2510 - Promijenjeno stanje DNA-metilacije u HPV-povezanim oštećenjima (Magdalena Grce, )
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CANCERLIT
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE
  • Biochemistry and Biophysics Citation Index
  • Chemical Citation Index
  • Beilstein Database
  • Elsevier BIOBASE/Current Advances in Biological Sciences
  • Pascal
  • Research Alert
  • SCISEARCH
  • Scopus
  • TOXFILE


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