Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles (CROSBI ID 131717)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Starčević, Kristina ; Kralj, Marijeta ; Ester, Katja ; Sabol, Ivan ; Grce, Magdalena ; Pavelić, Krešimir ; Karminski-Zamola, Grace
engleski
Synthesis, Antiviral and Antitumor Activity of 2- substituted-5-amidino-benzimidazoles
We have prepared a set of heterocyclic benzimidazole derivatives bearing amidino substituents at C-5 of benzimidazole ring, by introducing various heterocyclic nuclei (pyridine, N-methyl-pyrrole or imidazole) at C-2, and evaluated their antitumor and antiviral activities. The most pronounced antiproliferative activity was shown with compounds 6 and 9, having imidazolinylamidino-substituent. Interestingly, all compounds show remarkable selectivity towards breast cancer cell line MCF-7. The most distinct and selective antiviral activity towards Coxackieviruses and Echoviruses was observed with compounds having pyridine ring at C-2. Especially interesting was fairly strong activity of the compounds 4 and 8 toward adenoviruses, which could be considered as leads against adenoviral replication.
benzimidazoles; amidines; N-methylpyrrole; pyridine; imidazole; antiviral activity; antitumor activity
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Podaci o izdanju
15 (13)
2007.
4419-4426
objavljeno
0968-0896
10.1016/j.bmc.2007.04.032
Povezanost rada
Kemija, Temeljne medicinske znanosti