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Enhancement of intrinsic antitumor activity in spore- endotoxin mixtures of Bacillus thuringiensis by exposure to ultraviolet radiation

Irradiation of spore-endotoxin mixture from Bacillus thuringiensis cultures at 254 nm (60mW cm-1)enhances theirintrinscic antitumor potency as well as that either component. The extent of enhancement depends on the lenght og exposure (optimum 35 min)and may thas be due to photochemical changes of the endotoxin protein or/and to photoproduction of additional compounds with antitumor activity. Antitumor effects, expressed as survival rates of C57BL/6 mice inoculated wizh Lewi'smouse lung carcinoma and subjected to treatments 24 h later, depended on the number of doses of preparations administrated (mixture, separated components.)

antitumor activity ; spore-endotoxin mixtures ; Bacillus thuringiensis ; ultraviolet radiation.

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