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izvor podataka: crosbi

Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin (CROSBI ID 131613)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tomašić, Ana ; Bertoša, Branimir ; Tomić, Sanja ; Šoškić, Milan ; Magnus, Volker Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin // Journal of Chromatography A, 1154 (2007), 1-2; 240-249-x

Podaci o odgovornosti

Tomašić, Ana ; Bertoša, Branimir ; Tomić, Sanja ; Šoškić, Milan ; Magnus, Volker

engleski

Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin

The affinity of indole-3-acetic acid (IAA), indole-3-propionic acid, indole-3-butyric acid and 24 of their amino acid conjugates to immobilized human serum albumin, as expressed by the retention factor k (determined by HPLC), was dependent on (1) lipophilicity, (2) chirality and (3) functional groups in the amino acid moiety ; in some cases conformation plays an additional role. Two lipophilicity-related parameters afforded quantitative correlations with k: retention on a C-18 reversed-phase column (experimental approach) and the distance between the hydrophilic and hydrophobic poles of the molecules (in silico approach). Most compounds examined are possible metabolic precursors of IAA, an experimental tumor therapeutic.

indole-3-acetic acid; IAA; amino acid conjugate; human serum albumin; ligand binding; lipophilicity; molecular conformation

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Podaci o izdanju

1154 (1-2)

2007.

240-249-x

objavljeno

0021-9673

Povezanost rada

Fizika, Kemija, Biologija