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Pregled bibliografske jedinice broj: 295323

Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin


Tomašić, Ana; Bertoša, Branimir; Tomić, Sanja; Šoškić, Milan; Magnus, Volker
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin // Journal of Chromatography. A, 1154 (2007), 1-2; 240-249 (međunarodna recenzija, članak, znanstveni)


Naslov
Binding behavior of amino acid conjugates of indole-3-acetic acid to immobilized human serum albumin

Autori
Tomašić, Ana ; Bertoša, Branimir ; Tomić, Sanja ; Šoškić, Milan ; Magnus, Volker

Izvornik
Journal of Chromatography. A (0021-9673) 1154 (2007), 1-2; 240-249

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Indole-3-acetic acid; IAA; amino acid conjugate; human serum albumin; ligand binding; lipophilicity; molecular conformation

Sažetak
The affinity of indole-3-acetic acid (IAA), indole-3-propionic acid, indole-3-butyric acid and 24 of their amino acid conjugates to immobilized human serum albumin, as expressed by the retention factor k (determined by HPLC), was dependent on (1) lipophilicity, (2) chirality and (3) functional groups in the amino acid moiety ; in some cases conformation plays an additional role. Two lipophilicity-related parameters afforded quantitative correlations with k: retention on a C-18 reversed-phase column (experimental approach) and the distance between the hydrophilic and hydrophobic poles of the molecules (in silico approach). Most compounds examined are possible metabolic precursors of IAA, an experimental tumor therapeutic.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2829 - Molekularna regulacija biljnog razvitka (Branka Salopek-Sondi, )
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Sanja Tomić, )
178-0982929-2259 - Molekulsko prepoznavanje biljnih regulatora rasta (Milan Šoškić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Agronomski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts