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Pregled bibliografske jedinice broj: 293951

Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits


Campbell, Harry; Carothers, Andrew D.; Rudan, Igor; Hayward, Caroline; Biloglav, Zrinka; Barać, Lovorka; Peričić, Marijana; Janićijević, Branka; Smolej-Narančić, Nina; Polašek, Ozren et al.
Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits // Human Molecular Genetics, 16 (2007), 2; 233-241 (međunarodna recenzija, članak, znanstveni)


Naslov
Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits

Autori
Campbell, Harry ; Carothers, Andrew D. ; Rudan, Igor ; Hayward, Caroline ; Biloglav, Zrinka ; Barać, Lovorka ; Peričić, Marijana ; Janićijević, Branka ; Smolej-Narančić, Nina ; Polašek, Ozren ; Kolčić, Ivana ; Weber, James L. ; Hastie, Nicholas D. ; Rudan, Pavao ; Wright, Alan F.

Izvornik
Human Molecular Genetics (0964-6906) 16 (2007), 2; 233-241

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Inbreeding depression; founder population; human hypertension; complex traits; disease; association; loci; components; Drosophila; evolution

Sažetak
The dramatic changes in human population structure over the last 200 years have resulted in significant levels of outbreeding, which, in turn, is predicted to lead to increased levels of individual genetic diversity (genome-wide heterozygosity, h). To investigate possible effects of these large demographic changes on global health, we studied the effect of h, measured as relative heterozygosity, hR, on 15 disease-related traits in four groups of individuals with widely differing ancestral histories (ranging from outbred to inbred) from the Dalmatian islands in Croatia. Higher levels of hR, estimated using 1184 STR/indel markers, were found in the outbred group (P < 0.0001) and were associated with lower blood pressure (BP) and total/ LDL cholesterol (P 5 0.01 and 0.01, respectively) after controlling for other factors, with BP showing a strong sex effect (males P > 0.5 and females P 5 0.002). These findings, if replicated, suggest that hR be considered as a genetic risk factor in genetic epidemiological studies on common disease traits. They are consistent with the well-known effects of heterosis (hybrid vigour) described when outcrossing animals and plants. Outbreeding resulting from urbanization and migration from traditional population subgroups may be leading to increasing hR and may have beneficial effects on a range of traits associated with human health and disease. Other traits, such as age at menarche, IQ and lifespan, which have been changing during the decades of urbanization, may also have been influenced by demographic factors.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA


Projekt / tema
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Nina Smolej-Narančić, )
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Pavao Rudan, )
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Branka Janićijević, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Zagreb,
Institut za antropologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Excerpta Medica
  • Index Medicus
  • Elsevier BIOBASE/Current Awareness in Biological Sciences
  • Reference Update