engleski

Case of concurrent epidermolysis bullosa acquisita and anti-p200 pemphigoid - how to treat it?

Epidermolysis bullosa acquisita (EBA) is an uncommon, chronic, acquired, autoimmune, subepidermal blistering disease. The etiology of the disease is unknown. EBA antibodies bind to type VII collagen within anchoring fibrils at the dermo-epidermal junction. This results in a decreased number of anchoring fibrils, which therefore do not anchor the epidermis and its underlying basement membrane to the papillary dermis. To date, five clinical presentations of EBA have been described. 1 In general, the clinical features of classical EBA include increased skin fragility and skin lesions on the areas predisposed to trauma. EBA also affects the mucous membranes. The first two cases of EBA were reported and distinguished from dystrophic epidermolysis bullosa by Elliot in 1895. We present a patient with clinical, histological and immunological features of a mixture of EBA and anti-p200 pemphigoid.

epidermolysis bullosa acquisita; anti-p200 pemphigoid; treatment

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