The Novel Fluorinated C-6 Substituted Uracil Derivatives: Synthesis, Biological Evaluations, 1H And 13C NMR Conformational And X-Ray Crystal Structure Studies (CROSBI ID 526625)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Prekupec, Svjetlana ; Makuc, Damjan ; Krištafor, Vedran ; Cetina, Mario ; Lesjak, Danijela ; Plavec, Janez ; Kralj, Marijeta ; Pavelić, Krešimir ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen ; Raić-Malić, Silvana
engleski
The Novel Fluorinated C-6 Substituted Uracil Derivatives: Synthesis, Biological Evaluations, 1H And 13C NMR Conformational And X-Ray Crystal Structure Studies
Pyrimidine derivatives and their nucleosides have great biological significance because they exhibit a wide range of antiviral and anticancer activities. The pronounced biological activities exhibited by this class of compounds led us to synthesize the new type of C-6 alkylated pyrimidine derivatives and to evaluate their cytostatic and antiviral activities.1 Among all compounds evaluated, the compound containing a 2-hydroxy-3, 3, 3-trifluoro-1-propenyl side chain exhibited a pronounced effect against breast carcinoma (MCF-7), while the compound with a 2-fluoromethyl-2-acetoxypropyl chain exhibited moderate effect against cervical carcinoma (HeLa).2 A new series of the uracil derivatives with an acyclic side chain at the C-6 position was synthesized using lithiation of the 5, 6-dimethyl pyrimidine derivative and subsequent nucleophilic addition or substitution reactions of the organolithium intermediate thus obtained with fluorinated ketones and fluorinated esters. All synthesized compounds were evaluated for their cytostatic and antiviral activities.
pyrimidine derivatives; fluoroalkylated; NMR conformational analysis; antiviral activities; citostatic activities
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Podaci o prilogu
62-x.
2007.
objavljeno
Podaci o matičnoj publikaciji
XX. jubilarni hrvatski skup kemičara i kemijskih inženjera
Vasić-Rački, Đurđa
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
978-953-6894-29-1
Podaci o skupu
XX Jubilarni hrvatski skup kemičara i kemijskih inženjera.
poster
26.02.2007-01.03.2007
Zagreb, Hrvatska