engleski

Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (p<0.05). Statictical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (p<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (p<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degreadation of laminin was not connected with myofibroblastic stromal changes.

myofibroblasts; tenascin-C; laminin; prostate adenocarcinoma

nije evidentirano