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Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat related posttraumatic stress disorder


Pivac, Nela; Knežević, Jelena; Kozarić-Kovačić, Dragica; Deželjin, Martina; Mustapić, Maja; Rak, Davor; Matijević, Tanja; Pavelić, Jasminka; Muck-Šeler, Dorotea
Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat related posttraumatic stress disorder // Journal of Affective Disorders, 103 (2007), 1-3; 131-138 (međunarodna recenzija, članak, znanstveni)


Naslov
Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat related posttraumatic stress disorder

Autori
Pivac, Nela ; Knežević, Jelena ; Kozarić-Kovačić, Dragica ; Deželjin, Martina ; Mustapić, Maja ; Rak, Davor ; Matijević, Tanja ; Pavelić, Jasminka ; Muck-Šeler, Dorotea

Izvornik
Journal of Affective Disorders (0165-0327) 103 (2007), 1-3; 131-138

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Combat related posttraumatic stress disorder; MAO-B intron 13 polymorphism; platelet MAO-B activity; psychotic symptoms

Sažetak
The neurobiology of posttraumatic stress disorder (PTSD) involves alterations in multiple neuroendocrine and neurotransmitter systems. Platelet monoamine oxidase (MAO-B) has been associated with susceptibility to various psychiatric disorders, personality traits and behaviours. Platelet MAO-B activity and MAO-B intron 13 polymorphism (a G/A substitution) were determined in male war veterans (n=106) with DSM-IV diagnosed current and chronic PTSD, divided into subgroups of PTSD patients with (n=28) or without (n=78) psychotic features, combat exposed veterans (n=41) who did not develop PTSD, and healthy control men (n=242). Two-way ANOVAs revealed a significant effect of diagnosis and smoking, a significant effect of smoking, no significant effect of genotype, and no significant interaction between genotype, smoking or diagnosis, on platelet MAO-B activity. One-way ANOVAs showed significantly lower platelet MAO-B activity in smokers than in nonsmokers. After controlling for smoking, veterans with psychotic PTSD had significantly higher platelet MAO-B activity than veterans with or without PTSD, or healthy subjects. The results were obtained on peripheral biochemical marker, i.e. platelet MAO activity. The MAO-B intron 13 polymorphism was not functional, and did not affect platelet MAO-B activity. The aallele frequencies of the MAO-B genotype were similarly distributed among healthy controls and veterans with or without PTSD and/or psychotic symptoms. The results suggest that platelet MAO-B activity, controlled for smoking status, might be used as a peripheral marker of the psychotic symptoms in PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina



POVEZANOST RADA


Projekt / tema
065-0982464-2532 - Molekularni mehanizmi nastanka prekanceroznih i kanceroznih lezija usne šupljine (Marinka Mravak-Stipetić, )
098-0982464-2394 - Gensko liječenje tumora djelovanjem na molekule imunološkog sustava (Jasminka Pavelić, )
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Nela Pivac, )
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Dorotea Muck-Šeler, )
198-0982522-0075 - Psihofiziološka dijagnostika poremećaja uzrokovanih stresom (Dragica Kozarić-Kovačić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Klinička bolnica "Dubrava"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE