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Pregled bibliografske jedinice broj: 289147

Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives


Starčević, Kristina; Kralj, Marijeta; Ester, Katja; Karminski-Zamola, Grace
Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives // Heterocycles, 71 (2007), 3; 647-656 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and cytostatic evaluation of pyridopyrimidobenzimidazole derivatives

Autori
Starčević, Kristina ; Kralj, Marijeta ; Ester, Katja ; Karminski-Zamola, Grace

Izvornik
Heterocycles (0385-5414) 71 (2007), 3; 647-656

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pyridopyrimidobenzimidazole; cytostatic evaluation

Sažetak
A set of novel 2, 5-substituted benzimidazoles (1-7) and their cyclic derivatives (8-11) were synthesized and evaluated for their potential cytostatic effect on various tumor cell lines. The structures of the synthesized compounds were proved by means of IR, 1^H NMR and mass spectral data. Based on presented in vitro screening results we may conclude that cyclic compounds bearing nitro and amino substituents (10 and 11) showed the most pronounced growth inhibitory.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)
  • PASCAL/CNRS