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Pregled bibliografske jedinice broj: 284746

Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases.


Cairns, Nigel J; Grinberg, LT; Liščić, Rajka; Tu, Pang-hsien; Morris, John C.
Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases. // Journal of Neural Transmition
San Francisco, USA, 2006. str. VII-VII (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 284746 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases.

Autori
Cairns, Nigel J ; Grinberg, LT ; Liščić, Rajka ; Tu, Pang-hsien ; Morris, John C.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Neural Transmition / - , 2006, VII-VII

Skup
5th International Conference on Frontotemporal Dementia

Mjesto i datum
San Francisco, USA, 6-8.09.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Frontotemporal dementia; Frontotemporal lobar degeneration

Sažetak
Background: The clinical phenotype of frontotemporal dementia (FTD) encompasses two progressive patterns: gradual behavioral change and language disorder. Collectively, FTD may be caused by a diverse group of neurodegenerative diseases called frontotemporal lobar degenerations (FTLDs). New entities have been described and the nosology of FTLDs continues to evolve. Objective: To determine the type and frequency of FTLDs in a series using contemporary immunohistochemical methods. Methods: Eight hundred and thirty-three dementia cases were prospectively assessed at Washington University Alzheimer’ s Disease Research Center (WUADRC) and cases with clinical FTD were identified using existing diagnostic criteria and neuropathologic entities were ascertained using immunohistochemistry and contemporary diagnostic criteria. Results: Of the dementia cases, 53(6.3%) met clinical criteria for FTD ; 45(5.1%) fulfilled both clinical and neuropathological criteria for FTLD, and another 8 fulfilled only the clinical criteria. Forty percent of the cases were tauopathies: Pick’ s disease(n=3) ; corticobasal degeneration(n=11), argyrophilic grain disease(AGD, n=2), frontotemporal dementia with parkinsonism linked to chromosome 17(n=2), neurofibrillary tangle dementia(n=2), and one familial tauopathy with no tau mutation(n=1). However, most FTLD cases were characterized by ubiquitin-positive, tau-negative inclusions: FTLD with motor neuron disease-type inclusions (FTLD-MND-type, n=25, 47.2%), inclusion body myositis with Paget disease and frontotemporal dementia(IBMPFD, n=1), and diffuse leukoencephalopathy with neuroaxonal spheroids (DLN, n=3). Co-existing hippocampal sclerosis and AD-type changes were observed in 12 and 10 cases, respectively. Conclusion: Although FTLD-MND-type is the most frequent FTLD in this prospectively assessed series, less common entities not included in the McKhann criteria, such as AGD, DLS, and IBMPFD, may also present clinically as FTD and should be considered as part of the neuropathologic spectrum of FTLDs that clinic.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
0022009

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Rajka Liščić (autor)


Citiraj ovu publikaciju:

Cairns, Nigel J; Grinberg, LT; Liščić, Rajka; Tu, Pang-hsien; Morris, John C.
Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases. // Journal of Neural Transmition
San Francisco, USA, 2006. str. VII-VII (predavanje, međunarodna recenzija, sažetak, znanstveni)
Cairns, N., Grinberg, L., Liščić, R., Tu, P. & Morris, J. (2006) Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases.. U: Journal of Neural Transmition.
@article{article, author = {Cairns, Nigel J and Grinberg, LT and Li\v{s}\v{c}i\'{c}, Rajka and Tu, Pang-hsien and Morris, John C.}, year = {2006}, pages = {VII-VII}, keywords = {Frontotemporal dementia, Frontotemporal lobar degeneration}, title = {Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases.}, keyword = {Frontotemporal dementia, Frontotemporal lobar degeneration}, publisherplace = {San Francisco, USA} }
@article{article, author = {Cairns, Nigel J and Grinberg, LT and Li\v{s}\v{c}i\'{c}, Rajka and Tu, Pang-hsien and Morris, John C.}, year = {2006}, pages = {VII-VII}, keywords = {Frontotemporal dementia, Frontotemporal lobar degeneration}, title = {Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases.}, keyword = {Frontotemporal dementia, Frontotemporal lobar degeneration}, publisherplace = {San Francisco, USA} }




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