engleski

Immunological and non-immunological factors in predicting chronic kidney rejection

Chronic allograft dysfunction, which is the common cause of allograft failure, is in part caused by ongoing immune response. To prevent the significant degree of graft loss attributable to chronic kidney failure, we have to be able to identify patients at risk during the posttransplant period and monitor them. The prospective study of possible risk factors for chronic rejection (CR) based on three years follows up is the aim in this work. 315 primary kidney recipients whose graft survived more than one year were followed for a mean of 3.7 years. Kidney recipients with exhibiting a humoral response to the allograft demonstrate lower graft survival and increased risk for the development CR. 37.8% recipients had MHC-reactive alloantibodies 35, 2% failure among posttransplant positive patients (p=0.000002) statistically significant. The risk of CR was independent of severity and number acute rejection within first six months. The increase in serum creatinine level (SCr) occurred in different time following the MHC- alloantibodies. Our study includes a multivariate analysis of time to onset of first symptoms of CR, comparing the relative importance of immunological and non-immunological factors.

chronic kidney rejection; non-immunological factors; kidney transplantation

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