engleski

Endothelin-1, big endothelin-1 and nitric oxide in patients with chronic renal diseases

The complex pathogenesis of chronic renal disease (CRD) depends on endothelin axis (endothelins and endothelin receptors) as well as nitric oxide (NO) because of their vasoactive eff ects and role in the general modulation of vascular homeostasis. Distinct renal cells synthesize endothelins (ET) and NO that play a signifi cant role in renal hemodynamics as well as in water and salt excretion via urine. Endothelin-1 (ET-1) is a strong vasoconstrictor. Besides its vasoactive eff ects, ET-1 modulates mitosis and apoptosis in a cell type dependent manner, and may play an important role in CRD pathogenesis. The aims of this study were to determine the role and interactions of ET-1, big ET-1 and NO in CRD. Concentrations of these vasoactive molecules were measured in patients with diabetic nephropathy (group I), arterial hypertension (group II) and 1 (plasma and urine), big ET-1 (urine) and NO (serum and urine) were measured in CRD patients (n=57) and healthy controls (n=18). In CRD patients, the concentration of big ET-1 in urine was signifi cantly increased (13.13 pmol/L ; p<0.001) as compared to the control group (11.34 pmol/L). However, ET-1 values in plasma and urine showed no signifi cant changes. NO concentrations were also significantly increased in CRD patients (in serum: 72.55 &#956; mol/L, p<0.001 ; and in urine 141.74 &#956; mol/L, p<0.05) as compared to the control group. Study results indicated that big ET-1 and NO could be useful as diagnostic parameters for CRD because of their diagnostic sensitivity and diagnostic specifi city (for big ET-1 in urine: 56.1% and 88.9% ; and for NO in serum: 66.7% and 83.3%, respectively). In addition, big ET-1 may prove useful in the diff erential diagnosis of diabetic nephropathy (diagnostic sensitivity of 78.6% and diagnostic specifi city of 88.9%).

endothelin-1; big endothelin-1; nitric oxide; chronic renal diseases

nije evidentirano