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Pregled bibliografske jedinice broj: 283368

INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS


Filipović, Borid; Bach-Rojecky, Lidija; Lacković, Zdravko
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS // Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006 / Sinanović, Osman ; Škorbić, Helena (ur.).
Mostar: Udruženje neurologa u Bosni i Hercegovini, 2006. str. 307-308 (poster, domaća recenzija, sažetak, znanstveni)


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Naslov
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS

Autori
Filipović, Borid ; Bach-Rojecky, Lidija ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006 / Sinanović, Osman ; Škorbić, Helena - Mostar : Udruženje neurologa u Bosni i Hercegovini, 2006, 307-308

Skup
Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem

Mjesto i datum
Mostar, 9.-12. 11, 2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
botulinum toxin; orofacial pain; trigeminal ganglia

Sažetak
Aim. In the present study we investigated possible antinociceptive effect of botulinum toxin type A (BTX-A), injected into the trigeminal ganglion in orofacial pain in rats. Methods. Male Wistar rats were injected in right trigeminal ganglion with BTX-A 0.5 and 1 U/kg. Control rats were injected with saline. After 2-3 days, experimental orofacial pain was induced by one of the two inflammatory substances (1) formalin (2.5%) or (2) capsaicin (0.01%) which were injected into the right upper lip of rats. In both tests, the number of seconds that the animals spent rubbing/grooming the injected area was recorded. Statistical analysis was performed with Mann-Whitney U test. Results. BTX-A 1 U/kg, injected into the trigeminal ganglion 3 days before the induction of pain, significantly decreased the time that the rats spent rubbing the area injected with 0.01% capsaicin (rubbing time during 30 min for control: 219, 3&#61617; 24, 2 s vs. 132, 4&#61617; 17, 2 s for BTX-A-treatd animals, p<0.01). Intraganglionic injection of BTX-A in a dose 0.5 U/kg significantly reduced pain induced with formalin injection, too. The rubbing time was significantly decreased only in the second phase of the test (12-45 min following formalin injection). Rubbing time was 591, 9&#61617; 26, 1 s for control group vs. 444, 3&#61617; 31, 3 s for BTX-A-treated group (p<0.01). Conclusion. The present study demonstrates, for the first time, that low doses of BTX-A, applied in vivo into the trigeminal ganglion, reduce orofacial pain in rats.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
0108163

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Lidija Bach-Rojecky (autor)


Citiraj ovu publikaciju

Filipović, Borid; Bach-Rojecky, Lidija; Lacković, Zdravko
INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS // Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006 / Sinanović, Osman ; Škorbić, Helena (ur.).
Mostar: Udruženje neurologa u Bosni i Hercegovini, 2006. str. 307-308 (poster, domaća recenzija, sažetak, znanstveni)
Filipović, B., Bach-Rojecky, L. & Lacković, Z. (2006) INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS. U: Sinanović, O. & Škorbić, H. (ur.)Zbornik Radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006.
@article{article, year = {2006}, pages = {307-308}, keywords = {botulinum toxin, orofacial pain, trigeminal ganglia}, title = {INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS}, keyword = {botulinum toxin, orofacial pain, trigeminal ganglia}, publisher = {Udru\v{z}enje neurologa u Bosni i Hercegovini}, publisherplace = {Mostar} }
@article{article, year = {2006}, pages = {307-308}, keywords = {botulinum toxin, orofacial pain, trigeminal ganglia}, title = {INTRAGANGLIONIC INJECTION OF BOTULINUM TOXIN TYPE A REDUCES OROFACIAL PAIN IN RATS}, keyword = {botulinum toxin, orofacial pain, trigeminal ganglia}, publisher = {Udru\v{z}enje neurologa u Bosni i Hercegovini}, publisherplace = {Mostar} }




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