Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 283351

ZAGREB SPONTANEOUSLY CIRCLING RATS – A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER


Rebić, Veseljka; Lacković, Zdravko
ZAGREB SPONTANEOUSLY CIRCLING RATS – A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER // Zbornik radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006
Mostar: Udruženje neurologa u Bosni i Hercegovini, 2006. str. 323-324 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 283351 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
ZAGREB SPONTANEOUSLY CIRCLING RATS – A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER

Autori
Rebić, Veseljka ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006 / - Mostar : Udruženje neurologa u Bosni i Hercegovini, 2006, 323-324

Skup
Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem

Mjesto i datum
Mostar, 9-12. 11. 2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
movement disorders; spontaneously cycling rat; inheritance; dopamine

Sažetak
Experimentally induced asymmetrical circling behavior in rodents has been extensively investigated as an animal model of Parkinson disease and was found to be mediated by an imbalance of dopaminergic system. Several studies also reported circling behavior in rats that occurs spontaneously. Richter et al (Neuroscience, 1999) found spontaneously circling behavior (SCB) in an inbred LEW strain (c2), determined monogenetically by a recessive autosomal gene. Behavior pattern was characterized by rapid lateralized circling, hyperactivity, hyperexcitability, opisthotonus, moderate ataxia (Fedorowitz et al, Neuroscience 2000) and deafness, accompanied by bilateral vestibular dysfunction (Kaiser et al, Eur J Neurosci 2001). Neurochemically, c2 had lower tissue content of dopamine in the striatum ipsilateral to the preferred direction of rotation (Richter et al, Neuroscience 1999). Authors suggested c2 exhibits a complex syndrome, underlined by both dopaminergic and vestibular dysfunction. Lessenich et al (Neuroscience 2001) reported a new mutant rats with SCB (c3), differing both in gene location and phenotype compared to the c2. c3 rats exhibits SCB without deafness or obvious vestibular defects and without opisthotonus or ataxia, whereas neurochemical changes remains similar as in c2. Recently at animal house of Department of Pharmacology, Medical School of Zagreb we found a novel model of SCB among inbred WIST rats. Behavioral pattern shows both similarities and differences compared to c2/c3 models. Zagreb rats show rapid lateral circling with a higher turn rate than in c2/c3 models. There are no signs of opisthotonus and ataxia (as in c3), but rats exhibits strong and permanent head distortion to the side of preferred rotation, accompanied by spine distortion, which was not reported previously. Zagreb rats are unable to swim which may point to the vestibular dysfunction (as in c2). Test of rightening shows similar pattern to the one within c2/c3 models. Matting experiment that will reveal the mode of inheritance of the trait, and further neurochemical evaluations of possible dopaminergic imbalance are in progress, and results will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108163 - 0108163 (, )

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Zdravko Lacković (autor)

Avatar Url Veseljka Rebić (autor)

Citiraj ovu publikaciju

Rebić, Veseljka; Lacković, Zdravko
ZAGREB SPONTANEOUSLY CIRCLING RATS – A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER // Zbornik radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006
Mostar: Udruženje neurologa u Bosni i Hercegovini, 2006. str. 323-324 (poster, domaća recenzija, sažetak, znanstveni)
Rebić, V. & Lacković, Z. (2006) ZAGREB SPONTANEOUSLY CIRCLING RATS – A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER. U: Zbornik radova: Drugi kongres neurologa Bosne i Hercegovine s međunarodnim sudjelovanjem, Mostar 9-12. 11. 2006.
@article{article, year = {2006}, pages = {323-324}, keywords = {movement disorders, spontaneously cycling rat, inheritance, dopamine}, title = {ZAGREB SPONTANEOUSLY CIRCLING RATS and \#8211; A POSSIBLE NOVEL GENETIC MODEL OF MOVEMENT DISORDER}, keyword = {movement disorders, spontaneously cycling rat, inheritance, dopamine}, publisher = {Udru\v{z}enje neurologa u Bosni i Hercegovini}, publisherplace = {Mostar} }




Contrast
Increase Font
Decrease Font
Dyslexic Font