engleski

Evaluation of bone mineral density in patients with primary hyperparathyreoidism before and after surgical treatment

A sustained elevation in the secretion of parathyroid hormone (PTH) in most patients with primary hyperparathyroidism (PHPT) results in increased bone remodelling, demineralization, loss of skeletal mass and osteoporosis itself. It is expected that surgical removal of the parathyroid gland(s) in question results in both the cure and an improvement in bone mineral density. A clinical study was conducted involving 107 patients with PHPT hospitalized at our hospital in the paeriod from 1994-2000. PHPT was documented with elevated serum calcium, ionized calcium and PTH values. After surgical treatment all parameters were normalized. Dual Energy X-ray Absorptiometry (DEXA) was performed before and one year after parathyroidectomy. The results were statistically assessed using the Student T-test for paired samples. The results showed a statistically significant increase in bone mineral density one year after parathyroidectomy (total hip: p=0.025 ; : femoral neck: p=0.004 ; L2-L4: p=0.04). Conclusion: In pateints with primary hyperparathyroidism the bone mineral density significantly increases after surgical removal of hyperfunctional parathyroid gland.

bone mineral density; primary hyperparathyroidism

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