Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 281936

3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril


Tvrdeić, Ante; Cepanec, Ivica
3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril // Periodicum Biologorum, 108 (2006), Suppl 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)


CROSBI ID: 281936 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril

Autori
Tvrdeić, Ante ; Cepanec, Ivica

Izvornik
Periodicum Biologorum (0031-5362) 108 (2006), Suppl 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
3H-angiotensin II; isolated glomeruli; drugs

Sažetak
In an attempt to characterise, optimise and standardise conditions for 3H-angiotensin II binding to AT1 angiotensin receptors from isolated rat glomeruli, the effect of angiotensin II, angiotensin I, lisinopril and valsartan were investigated. In concentrations ranging from 100 pM to 100 nM, angiotensin II displaced 3H-angiotensin II binding to isolated rat glomeruli with highest affinity (IC50 = 11.8 nM). Angiotensin I also inhibited 3H-angiotensin II binding to isolated rat glomeruli, but with two orders of magnitude weaker affinity as compared to angiotensin II. Furthermore, lisinopril, an angiotensin convertase enzyme inhibitor, enhanced 3H-angiotensin II binding to isolated rat glomeruli, in concentration independent manner. Finally, valsartan, high specific and selective competitive antagonist at AT1 angiotensin receptors showed quite unusual binding interaction with angiotensin receptors from isolated rat glomeruli. In nanomolar concentrations, valsartan enhanced 3H-angiotensin II binding. Besides, valsartan changed the shape of binding curve for angiotensin II from classical, displacement curve (angiotesin II alone) into biphasic curve (enhancement of 3H-angiotensin II binding with low nanomolar concentrations, followed by displacement of 3H-angiotensin II binding with high nanomolar concentrations). In conclusion, the results presented here, indicate an unknown, non-competitive interaction of valsartan with angiotensin receptors from isolated rat glomeruli labelled with 3H-angiotensin II.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0219081

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Ivica Cepanec (autor)

Avatar Url Ante Tvrdeić (autor)


Citiraj ovu publikaciju

Tvrdeić, Ante; Cepanec, Ivica
3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril // Periodicum Biologorum, 108 (2006), Suppl 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)
Tvrdeić, A. & Cepanec, I. (2006) 3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril. Periodicum Biologorum, 108 (Suppl 1).
@article{article, year = {2006}, pages = {20}, keywords = {3H-angiotensin II, isolated glomeruli, drugs}, journal = {Periodicum Biologorum}, volume = {108}, number = {Suppl 1}, issn = {0031-5362}, title = {3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril}, keyword = {3H-angiotensin II, isolated glomeruli, drugs} }
@article{article, year = {2006}, pages = {20}, keywords = {3H-angiotensin II, isolated glomeruli, drugs}, journal = {Periodicum Biologorum}, volume = {108}, number = {Suppl 1}, issn = {0031-5362}, title = {3H- angiotensin II binding to rat isolated glomeruli - the effects of valsartan, angiotensin II, angiotensin I and lisinopril}, keyword = {3H-angiotensin II, isolated glomeruli, drugs} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





Contrast
Increase Font
Decrease Font
Dyslexic Font