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Pregled bibliografske jedinice broj: 280607

Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia


Galešić, Krešimir; Božić, Borka; Račić, Ivana; Sčukanec-Špoljar, Mira
Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia // Nephrology, 11 (2006), 1; 49-52 doi:10.1111/j.1440-1797.2006.00524.x (recenziran, članak, stručni)


Naslov
Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia

Autori
Galešić, Krešimir ; Božić, Borka ; Račić, Ivana ; Sčukanec-Špoljar, Mira

Izvornik
Nephrology (1320-5358) 11 (2006), 1; 49-52

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Chronic myeloid leukaemia; interferon; nephrotic syndrome; renal failure; thrombotic microangiopathy

Sažetak
The association of interferon(IFN)therapy with haemolytic uraemic syndrome in patients with chronic myeloid leukaemia(CML)has been reported infrequently.The pathogenesis of the renal lesion in such cases remains unclear.We report the case of a patient with CML who developed nephrotic syndrome and renal failure while being treated with hydroxyurea and IFN-alpha.Renal biopsy showed features of chronic thrombotic microangiopathy.The discontinuation of IFN-alpha, and a prompt institution of plasmapheresis and steroids resulted in improvement of the nephrotic syndrome and renal function.These findings suggest that longterm IFN-alpha therapy can induce thrombotic microangiopathy and haemolytic uraemic syndrome in patients with CML.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0108254

Ustanove
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • MEDLINE


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