Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia (CROSBI ID 128711)
Prilog u časopisu | stručni rad
Podaci o odgovornosti
Galešić, Krešimir ; Božić, Borka ; Račić, Ivana ; Sčukanec-Špoljar, Mira
engleski
Thrombotic microangiopathy associated with alpha-interferon therapy for chronic myeloid leukaemia
The association of interferon(IFN)therapy with haemolytic uraemic syndrome in patients with chronic myeloid leukaemia(CML)has been reported infrequently.The pathogenesis of the renal lesion in such cases remains unclear.We report the case of a patient with CML who developed nephrotic syndrome and renal failure while being treated with hydroxyurea and IFN-alpha.Renal biopsy showed features of chronic thrombotic microangiopathy.The discontinuation of IFN-alpha, and a prompt institution of plasmapheresis and steroids resulted in improvement of the nephrotic syndrome and renal function.These findings suggest that longterm IFN-alpha therapy can induce thrombotic microangiopathy and haemolytic uraemic syndrome in patients with CML.
chronic myeloid leukaemia; interferon; nephrotic syndrome; renal failure; thrombotic microangiopathy
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti