engleski

The frequency of impaired glucose and lipid metabolism in obesity

The aim of this investigation was to establish the relationship between obesity and IGT, DM and lipid metabolism disorders. Methods: The study included 251 persons divided into 3 groups according to their body mass index (BMI): the control group 1 (G1) comprised subjects with BMI <25 (N=46), group 2 (G2) included subjects with BMI >25, <30 (N=105), and group 3 (G3) subjects with BMI >30 (N=100). All subjects underwent standard OGTT and fasting lipidogram (typization according to Fredrickson). Results: There was a statistically significant difference in the occurrence of IGT and DM in G2 and G3 as compared with G1 (p<0.01). A statistically significant difference in fasting and post-load glycemia values was found between G2 and 3 as compared to G1 (p<0.01). A statistically significant positive correlation was found between glycemia and BMI (p<0.01). There was no statistically significant difference in the occurrence of pathological lipidograms between G2 and G3 as compared to G1. A statistically significant difference in HDL cholesterol (p<0.02) and triglycerides (p<0.01) was found between G3 and G1. A statistically significant correlation with BMI was found for HDL cholesterol (negative) and for triglycerides (positive). Conclusion: Group 2 and Group 3 comprised statistically significantly more patients with IGT and NIDDM than the control group. Fasting and post-load glycemia were statistically significantly lower in G1 as compared to G2 and G3. There were no statistically significant differences between the examined groups in the representation of pathological lipidograms. A statistically significant difference in HDL cholesterol and triglycerides was established between Group 1 and Group 3.

obesity; impaired glucose tolerance; diabetes mellitus; lipids

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