engleski

The role of adhesion molecules in pathogenesis of acute ischemic stroke

Sixty-seven subjects with acute ischemic stroke and 76 healthy controls were enrolled in this study. At the patient admission, the concentration of soluble adhesion molecules, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and total leukocyte count were determined. The concentrations of soluble adhesion molecules were determined using quantitative sandwich enzyme immunoassay. On the following morning, fasting blood glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-concentrations were determined in patient sera. The mean levels of cell adhesion molecule – 1 (ICAM-1), vascular cell adhesion molecule – 1 (VCAM-1) and sE-selectin were higher in patients with acute ischemic stroke than in controls (P<0.001, 0.034, 0.002, retrospectively), whereas sL-selectin was lower in patients (P=0.043). In patients, levels of soluble adhesion molecules were independent of age, with the exception of sL-selectin, which inversely correlated with age (r=-0.260, P=0.034). In controls, sICAM-1 and sVCAM-1 increased with age (r=0.301, P=0.008 and r=0.524, P<0.001, respectively). SL-selectin was higher in diabetics (n=14 ; P=0.004). In patients, soluble adhesion molecule levels did not differ with respect to carotid atherosclerotic disease, smoking status, hypertension and hypercholesterolemia. Some soluble adhesion molecules correlated with blood glucose, lipid parameters and the markers of inflammation. The acute ischemic stroke is associated with elevated plasma levels of inflammatory adhesion molecules independently of age, sex and other recognized stroke risk factors. That increase is an indicator of inflammatory process and is most probably transient in nature. Increased triglycerides, cholesterol and glucose correlate with moderately elevated concentrations of adhesion molecules in asymptomatic individuals pointing to chronic inflammatory activation of endothelium.

adhesion molecules; acute stroke

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