Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 279043

Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice


Rumora, Lada; Lovrić, Jasmina; Sairam, M. Ram; Maysinger, Dusica
Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice // Book of Abstracts of the HDBMB2006, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation / Kovarik, Zrinka (ur.).
Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju, 2006. (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 279043 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice

Autori
Rumora, Lada ; Lovrić, Jasmina ; Sairam, M. Ram ; Maysinger, Dusica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of the HDBMB2006, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation / Kovarik, Zrinka - Zagreb : Hrvatsko društvo za biokemiju i molekularnu biologiju, 2006

Skup
Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation

Mjesto i datum
Vodice, Hrvatska, 03-07.10.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
gonadotropins; sex hormones; MAPKs; Hsps

Sažetak
Decline in androgens in males (andropause) and oestrogens in females (menopause) during aging increase the risk of osteoporosis, obesity, cardiovascular diseases, type 2 diabetes and of functional impairments of the central nervous system. We assessed the status of heat shock proteins (Hsps) and mitogen-activated protein kinases (MAPKs) in the hippocampus and the cortex of follitropin receptor knockout (FORKO) mice with enhanced LH and FSH together with estradiol and testosterone imbalance, as a consequence of FSH-R deletion. In the hippocampus, the expression of Hsp70 and Hsp25 was reduced in 20 months old FORKO males and both Hsps were significantly more down-regulated in age-matched females. In addition, female FORKO mice exhibited enhanced P-ERK already at 3 months of age while these changes become significant only in 20 months old male knockouts. In the cortex, the expression of Hsp70 and Hsp25 was significantly lower in older females. The signal intensity of P-ERK was strong in both genders. Functional characteristics of MAPKs are dependent on their subcellular localization. In the hippocampus of 12 months old FORKO females translocation of P-ERK to the nucleus decreased and more cytosolic P-ERK was found then in the age-matched wild type animals. On the other hand, nuclear P-JNK was significantly reduced whereas it was markedly enhanced in the mitochondria of the cortex of 20 months old FORKO males. In summary, enhanced gonadotropins alone or in combination with sex hormone imbalance in aging lead to biochemical changes in CNS in terms of disturbed Hsps expression, activation and subcellular distribution of MAPKs, and those changes could present a risk factor for neurodegeneration in menopause and late andropause.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0006631
0006561

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Rumora, Lada; Lovrić, Jasmina; Sairam, M. Ram; Maysinger, Dusica
Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice // Book of Abstracts of the HDBMB2006, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation / Kovarik, Zrinka (ur.).
Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju, 2006. (poster, domaća recenzija, sažetak, znanstveni)
Rumora, L., Lovrić, J., Sairam, M. & Maysinger, D. (2006) Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice. U: Kovarik, Z. (ur.)Book of Abstracts of the HDBMB2006, Congress of the Croatian Society of Biochemistry and Molecular Biology with international participation.
@article{article, editor = {Kovarik, Z.}, year = {2006}, pages = {129}, keywords = {gonadotropins, sex hormones, MAPKs, Hsps}, title = {Disturbed Hsps expression and MAPKs activation in the hippocampus and the cortex of FORKO mice}, keyword = {gonadotropins, sex hormones, MAPKs, Hsps}, publisher = {Hrvatsko dru\v{s}tvo za biokemiju i molekularnu biologiju}, publisherplace = {Vodice, Hrvatska} }