Frequency of TNF-alpha +489G/A polymorphism in patients with chronic obstructive pulmonary disease (CROSBI ID 524075)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Malić, Ana ; Smoljanović, Jelena ; Čepelak, Ivana ; Rumora, Lada ; Grdić, Marija ; Popović-Grle, Sanja ; Barišić, Karmela
engleski
Frequency of TNF-alpha +489G/A polymorphism in patients with chronic obstructive pulmonary disease
Tumor necrosis factor (TNF)– alpha, pro-inflammatory cytokine, plays an important role in inflammatory processes. Several biallelic polymorphisms of the gene coding for TNF-alpha (located on chromosome 6 in the class III region of the major histocompatibility complex) are known. Some of them have been reported to be associated with chronic inflammatory diseases. Chronic obstructive pulmonary disease (COPD) is characterised by enhanced level of TNF-alpha in sputum and in circulation indicating that this cytokine is involved in both the local and systematic inflammation present in COPD. Analysis of possible TNF-alpha gene polymorphisms in COPD could be related to a higher susceptibility to develop this disabling pathological condition. We analysed TNF-alpha gene polymorphism at position +489G/A located in the first intron of the gene which has been reported to be associated with COPD in Dutch population. Polymorphism at position +489G/A of TNF-alpha gene was examined in 31 COPD patients and in 51 healthy volunteers by PCR-RFLP procedure. We found following genotype frequencies in the group of COPD patients: AG 0.39, GG 0.61, and AA 0.00 ; and in the control group: AG 0.53, GG 0.45, and AA 0.02. There were no differences on the allele and genotype frequency between the two groups (P=0, 299). We could not find a significant link between the +489G/A polymorphism of TNF-alpha gene and COPD in Croatian population.
TNF-alpha; Chronic obstructive pulmonary disease; Polymorphism
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
114-114.
2006.
objavljeno
Podaci o matičnoj publikaciji
Book of abstract Congress of the Croatian Society of Biochemistry and Molecular Biology on the occasion of the 30th Anniversary with international participation
Kovarik, Zrinka
Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB)
Podaci o skupu
Congress of the Croatian Society of Biochemistry and Molecular Biology on the Occasion of the 30th Anniversary with international participation
poster
03.10.2006-07.10.2006
Vodice, Hrvatska