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The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon


Miše, Stjepan; Tonkić, Ante; Pešutić-Pisac, Valdi; Tonkić, Marija; Miše, Sandro; Capkun, Vesna; Batelja, Lovorka; Blagaić Boban, Alenka; Kokić, Neven; Zoričić, Ivan et al.
The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon // Medical science monitor, 12 (2006), 4; 146-153 (međunarodna recenzija, članak, znanstveni)


Naslov
The presentation and organization of adaptive cytoprotection in the rat stomach, duodenum, and colon

Autori
Miše, Stjepan ; Tonkić, Ante ; Pešutić-Pisac, Valdi ; Tonkić, Marija ; Miše, Sandro ; Capkun, Vesna ; Batelja, Lovorka ; Blagaić Boban, Alenka ; Kokić, Neven ; Zoričić, Ivan ; Saifert, Davor ; Anić, Tomislav ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Medical science monitor (1234-1010) 12 (2006), 4; 146-153

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Stomach; duodenum; colon; adaptive cytoprotection; rat

Sažetak
Adaptive cytoprotection could be demonstrated in lesion attenuation within the whole gastrointestinal tract, in particular sequences, with onset and duration longer than the initial short-lasting period (i.e. one hour) defined by Robert in the stomach only. MATERIAL/METHODS: Adaptive cytoprotection possibly appeared and lesions were attenuated when the stomach, duodenum or colon, in various combinations and sequences, were challenged with initial (mild) and/or final (strong) irritants over a two-week period. Rats were challenged with the mild or strong irritants 25% or 96% ethanol intragastrically 1 ml/rat (stomach) and cysteamine 40 mg or 400 mg/kg subcutaneously (duodenum), or intrarectally (colon). To postulate the prostaglandin relationship known in Robert's cytoprotection and adaptive cytoprotection, indomethacin (1 mg/kg subcutaneously) was given simultaneously with the second challenge. RESULTS: Administering the mild and strong irritant protocols within the same part of the gastrointestinal tract, adaptive cytoprotection presents in the stomach (1 h to 14 days), duodenum (2 h to 14 days), but not in the colon. With these protocols applied to different parts of the gastrointestinal tract, adaptive cytoprotection cross-reaction was evident in the stomach-duodenum, duodenum-stomach (1 h-14 days and 2 h-14 days), stomach-colon, and duodenum-colon (both 2-24 hours), but not in the colon-stomach or colon-duodenum. This protection was fully antagonized with indomethacin. CONCLUSIONS: As observed for a day and even weeks, stomach-duodenum-colon adaptive cytoprotection is an important new defensive phenomenon.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE