engleski

How to monitor vascular aging with ultrasound

Nema.Background and aim: The discrimination between the tems "vascular disease" and "vascular aging - vascular disease interaction" can be used for active health patrolling and disease prevention. Our aim was to set age standards for vascular ultrasound parameters usable in epidemiological studies. Patients and methods: Investigation was conducted on healthy volunteers (age range 25-75 years). Several parameters were evaluated: intima-media thickness (IMT), diameter change and eircumferential arterial stiffiiess (CAS) on common carotid al-tery (CCA) as well as resistance (RI), pulsatility (PI) and A/'B indexes. Measurements were performed on Aloka 5500-SSD Prosound ultrasound platform in B and M modes by standard protocols. ANOVA statistics was used for evaluation. Results: There were 104 womenand 46 men, 20% were hypertensive (all values still within the normcil range), 24% were overweight and 13% were active smokers. Investigated vascular parameters were within the normal age. IMT values bilaterally, RI on the right CCA, interadventitial diameters and CAS on the right CCA were found dependent to age as was (p<0, 05). PI, A/B index, luminal diameters were not found age dependant (p>0, 05). Discussion: Increased carotid thickening and stiffness with endothelial dysfunction are a part of normal aging process as well as an increase in systolic blood prcssure and pulse pressure values and are referred to as vascular remodeling. Since some of the changes attributed to normal aging have been identitied in hypertensive individuals at an earlier age it is believed that they can be recognized as "unsuccessful" aging and subclinical vascular disease. Conclusion: Ultrasound can be usefull to determine proper vascular age of individuals offering proposition of different strategies for reduction or retardation of clinical manifestation of cerebrovascular disease.

ultrasound; vascular disease; vascular aging

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