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ANTIVIRAL ACTIVITY AND FLAVONOID CONTENT OF PROPOLIS FROM CROATIA AND BRAZIL


Kosalec, Ivan; Serkedjieva, Julia; Oršolić, Nada; Bakmaz, Marina; Pepeljnjak, Stjepan
ANTIVIRAL ACTIVITY AND FLAVONOID CONTENT OF PROPOLIS FROM CROATIA AND BRAZIL // Zbornik radova 9. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem / Besendorfer, Višnja ; Klobučar Goran (ur.).
Zagreb, 2006. (poster, domaća recenzija, sažetak, znanstveni)


Naslov
ANTIVIRAL ACTIVITY AND FLAVONOID CONTENT OF PROPOLIS FROM CROATIA AND BRAZIL

Autori
Kosalec, Ivan ; Serkedjieva, Julia ; Oršolić, Nada ; Bakmaz, Marina ; Pepeljnjak, Stjepan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik radova 9. hrvatskog biološkog kongresa s međunarodnim sudjelovanjem / Besendorfer, Višnja ; Klobučar Goran - Zagreb, 2006

Skup
9. Hrvatski biološki kongres

Mjesto i datum
Rovinj, Hrvatska, 23-29.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Propolis; Croatia; Brazil; antiviral; HSV; influenza viruses

Sažetak
The flavonoids and phenolic acids and their esters present in propolis are considered to be a rich source of chemopreventive agents, since they possess various biological activities. We investigated water and ethanolic extracts of two chemotypes of propolis (poplar-type from Croatia, and alecrim-type from Brazil) with respect to their chemical composition and antiviral effects. The flavonoid content was anlyzed using two complementary colorimetric methods for flavones/flavonols and flavanones and dihydroflavonols. The samples as well as the main compounds present in propolis: naringenin, quercetin, chrysin, galangin and caffeic acid were tested for inhibitory activity on the replication of influenza viruses A/Germany/27, strain Weybridge (H7N7) and A/Aichi/2/68 (H3N2) in MDCK cells and herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) in MDBK cells. Cytopathic effect was used as a measure of viral replication and the selectivity of inhibition was evaluated. The water and ethanolic extracts from Brazilian propolis as well as naringenin and caffeic acid significantly inhibited the growth of A/Weybridge with selectivity indices (SI) 15, 10, 10 and 6 respectively. None of the tested compounds showed antiviral activity against A/Aichi. Both water propolis extracts from Croatian and Brazilian sources as well as galangin and quercetin exhibited strong anti-HSV-1activity, with SI 20, 16.7, 15 and 10 respectively. The Brazilian water extract of propolis was less effective towards HSV-2 as was quercetin with SI 7.1 and 4 respectively. No correlation between flavonoids content and antiviral activity was observed.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekt / tema
0006641
0048003

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Hrvatski veterinarski institut, Zagreb