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Polyphenolic compounds from propolis modulate immune responses and increase host resistance to tumor cells

Propolis contains a variety of polyphenolic compounds. We investigated the effect of water-soluble derivative of propolis (WSDP) and polyphenolic compounds, components of propolis, on growth of Ehrlich ascites tumor (EAT) in the mouse. Tumor in peritoneal cavity was produced by 2 x 106 EAT cells. WSDP and polyphenolic compounds (caffeic acid-CA, caffeic acid phenethyl ester-CAPE and quercetin-QU) were given to mice perorally (po). It was found that the volume of ascitic fluid induced by EAT cells and total number of cells present in the peritoneal cavity was markedly reduced in EAT-bearing mice treated with test components and the survival time of treated mice was prolonged. Inhibition of EAT growth was due to their effect on the immune system of mice. When innate and acquired immune responses were evaluated, a dose-related increase of cytotoxic T-cell, NK and B cells activity was observed in test components-treated mice. Furthermore, exposure of animals to test components increased functional activity of macrophages to produce factors regulating the function of B-, T-, and NK- cells respectively. In conclusion, these findings implie that the antitumor activity of WSDP and polyphenolic compounds of propolis enhanced host resistance in the EAT tumor model, increasing in the activities of macrophages, cytotoxic T cells, B cells and NK cells.

polyphenolic compounds; immunomodulation; tumor; host resistance

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