engleski

Antimetastatic effect of honey

We investigated the antimetastatic efficiency of honey. Transplantable murine tumors were used: a spontaneous mammary carcinoma (MCa) and a methylcholanthrene&#8211; induced fibrosarcoma (FS) of CBA mouse and an anaplastic colon adenocarcinoma (ACa) of Y59 rat. Metastases in the lung were generated by injecting viable tumor cells intravenously (iv). A pronounced antimetastatic effect (p < 0.01 ; 0.001) was achived by oral application of honey given before tumor cell inoculation (2 gr/kg for mice or 1 gr/kg for rats, once a day for 10 consecutive days) ; however given after tumor cell inoculation honey enhanced lung metastases. To conclude honey given orally before tumor cell inoculation may have an impact on tumor spread.

honey; tumor; metastasis; mouse; rat

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