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The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines (CROSBI ID 128118)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Žinić, Mladen ; Pawlica, Dariusz ; Eilmes, Julita The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines // Bioorganic & medicinal chemistry, 15 (2007), 4; 1795-1801. doi: 10.1016/j.bmc.2006.11.034

Podaci o odgovornosti

Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Žinić, Mladen ; Pawlica, Dariusz ; Eilmes, Julita

engleski

The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines

Three dibenzotetraaza[14]annulenes non-covalently interacted with double stranded DNA and RNA by mixed minor groove and/or intercalative binding mode. Observed interactions were strongly dependent on the steric exposure of positive charges and the length of the linkers of studied compounds as well as on the secondary structure and basepair composition of DNA/RNA. Compound 2 showed pronounced selectivity toward dA - dT rich sequences, and binding mode switch from dominant minor groove binding to ds-DNA to dominant intercalation into ds-RNA. Antiproliferative effect of studied compounds on human tumor and normal cell lines was in good agreement with the strength of observed interactions with DNA/RNA.

antitumour agents ; dibenzotetraaza[14]annulenes ; DNA sequence selectivity ; intercalation ; groove binding

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Podaci o izdanju

15 (4)

2007.

1795-1801

objavljeno

0968-0896

1464-3391

10.1016/j.bmc.2006.11.034

Povezanost rada

Kemija, Temeljne medicinske znanosti

Poveznice