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The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines


Radić Stojković, Marijana; Piantanida, Ivo; Kralj, Marijeta; Marjanović, Marko; Žinić, Mladen; Pawlica, Dariusz; Eilmes, Julita
The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines // Bioorganic and Medicinal Chemistry, 15 (2007), 4; 1795-1801 (međunarodna recenzija, članak, znanstveni)


Naslov
The dicationic derivatives of DBTAA. Interactions with DNA/RNA and antiproliferative effects on human cell lines

Autori
Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Žinić, Mladen ; Pawlica, Dariusz ; Eilmes, Julita

Izvornik
Bioorganic and Medicinal Chemistry (0968-0896) 15 (2007), 4; 1795-1801

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antitumour agents; dibenzotetraaza[14]annulenes; DNA sequence selectivity; intercalation; groove binding

Sažetak
Three dibenzotetraaza[14]annulenes non-covalently interacted with double stranded DNA and RNA by mixed minor groove and/or intercalative binding mode. Observed interactions were strongly dependent on the steric exposure of positive charges and the length of the linkers of studied compounds as well as on the secondary structure and basepair composition of DNA/RNA. Compound 2 showed pronounced selectivity toward dA - dT rich sequences, and binding mode switch from dominant minor groove binding to ds-DNA to dominant intercalation into ds-RNA. Antiproliferative effect of studied compounds on human tumor and normal cell lines was in good agreement with the strength of observed interactions with DNA/RNA.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
098-0982904-2912 - Samo-udruživanje u gelovima i sinteza funkcionalnih hibridnih materijala (Leo Frkanec, )
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE