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The herpesviral Fc eceptor fcr-1 as a potent Down-regulator of the NKG2D ligand MULT-1 and H60


Lenac, Tihana; Budt, Matthias; Arapović, Jurica; Hasan, Milena; Zimmermann, Albert; Šimić, Hrvoje; Krmpotić, Astrid; Messerle, Martin; Ruzsics, Zsolt; Koszinowski, Ulrich H. et al.
The herpesviral Fc eceptor fcr-1 as a potent Down-regulator of the NKG2D ligand MULT-1 and H60 // Abstracts of the 1st Joint Meeting of European National Societies of Immunology ang the 16th European Congress of Immunology
Pariz, Francuska, 2006. (poster, sažetak, znanstveni)


Naslov
The herpesviral Fc eceptor fcr-1 as a potent Down-regulator of the NKG2D ligand MULT-1 and H60

Autori
Lenac, Tihana ; Budt, Matthias ; Arapović, Jurica ; Hasan, Milena ; Zimmermann, Albert ; Šimić, Hrvoje ; Krmpotić, Astrid ; Messerle, Martin ; Ruzsics, Zsolt ; Koszinowski, Ulrich H. ; Hengel, Hartmut ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 1st Joint Meeting of European National Societies of Immunology ang the 16th European Congress of Immunology / - , 2006

Skup
Meeting of European National Societies of Immunology (1 ; 2006) ; European Congress of Immunology (16 ; 2005)

Mjesto i datum
Pariz, Francuska, 06.-09.09.2006.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Neobjavljeni rad

Ključne riječi
Fcr-1; NKG2D; MULT-1; H60

Sažetak
Members of the alpha- and beta- subfamily of herpesviridae encode glycoproteins that specifically bind to the Fc part of IgG. Plasma membrane resident herpesviral Fc receptors seem to prevent virus-specific IgG from activating antibody dependent effector functions. We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 is able to down-regulate NKG2D ligands MULT-1 and H60. fcr-1 promotes rapid down-regulation of MULT-1 from the surface of infected cells to a lysosomal compartment for proteolytic degradation via clathrin-dependent endocytosis. Removal of MULT-1 from the plasma membrane by fcr-1 occured independent of, but in cooperation with the second MCMV inhibitor of MULT-1, m145. Deletion of the fcr-1/m138 gene from the MCMV genome attenuated viral replication to NK cell responses in vivo. A distinct N’ terminal module within the fcr-1 ectodomain was necessary and sufficient to impair MULT-1 surface expression. In contrast, down-modulation of H60 required the complete fcr-1 ectodomain, implying independent modes of fcr-1 interaction with the NKG2D ligands. The results establish a novel viral strategy for down-modulating NK cell responses and highlight the impressive diversity of Fc receptor functions.

Izvorni jezik
Engleski



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