engleski

Vascular Cell Adhesion Molecule-1 In Patients With Different Pathogenetical Type Of Ischemic Stroke

Activation of endothelial cells, expression of soluble adhesion molecules and transendothelial migration of leukocytes play an important role in inflammation and progression of ischemic injury after acute stroke. The aim of this study was to determine serum levels of VCAM-1 in patients with acute ischemic stroke and controls and correlate them according to etiological subtypes (thromboembolic or lacunar stroke). We enrolled 110 patients with acute ischemic stroke as well as 93 healthy individuals as controls. Serum concentrations of VCAM-1 were determined by means of quantitative sandwich enzyme immunoassay. Levels of VCAM-1 were significantly higher in patients with thromboembolic stroke than in controls. This study confirms the role of adhesion molecule VCAM-I in the pathogenesis of acute thromboembolic stroke.

Adhesion molecule; stroke; etiology

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