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Pregled bibliografske jedinice broj: 273850

Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids


Chen, Tong-Bin; Huzak, Miljenko; Macura, Slobodan; Vuk-Pavlović, Stanimir
Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids // Cancer Letters, 86 (1994), 1; 41-51 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 273850 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids

Autori
Chen, Tong-Bin ; Huzak, Miljenko ; Macura, Slobodan ; Vuk-Pavlović, Stanimir

Izvornik
Cancer Letters (0304-3835) 86 (1994), 1; 41-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
5-Fluorouracil; 5-Fluorouridine; Octreotide; NMR spectroscopy; Multicell spheroids; Colon adenocarcinoma HT-29 cells

Sažetak
To examine if preferential retention of somatostatin analogues observed in some tumors might be used for modulation of effects of cancer drugs by co-treatment with long acting somatostatin analogues, the effects of somatostatin analogue octreotide on the kinetics of 5-fluorouracil (FUra) and 5-fluorouridine (FUrd) metabolism were studied by ^19 F NMR spectroscopy in multicell tumor spheroids comprised of human colon HT-29 adenocarcinoma cells. Octreotide stimulated the rate of formation of fluorouridinephosphates in FUra-treated cells, but inhibited this rate in FUrd-treated cells. Other elements of fluoropyrimidine metabolism were also altered by co-incubation with octreotide. A flow cytometric analysis indicated that FUra and FUrd arrested cells in S phase, but co-treatment with octreotide almost eliminated the S-phase cells and induced the appearance of DNA fragments. These observations raise the possibility that somatostadin analogues can be used for specific modulation of fluoropyrimidine effects in tumors bearing somatostatin receptors.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
1-01-250

Ustanove:
Prirodoslovno-matematički fakultet, Matematički odjel, Zagreb

Profili:

Avatar Url Miljenko Huzak (autor)

Avatar Url Stanimir Vuk-Pavlović (autor)


Citiraj ovu publikaciju

Chen, Tong-Bin; Huzak, Miljenko; Macura, Slobodan; Vuk-Pavlović, Stanimir
Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids // Cancer Letters, 86 (1994), 1; 41-51 (međunarodna recenzija, članak, znanstveni)
Chen, T., Huzak, M., Macura, S. & Vuk-Pavlović, S. (1994) Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids. Cancer Letters, 86 (1), 41-51.
@article{article, year = {1994}, pages = {41-51}, keywords = {5-Fluorouracil, 5-Fluorouridine, Octreotide, NMR spectroscopy, Multicell spheroids, Colon adenocarcinoma HT-29 cells}, journal = {Cancer Letters}, volume = {86}, number = {1}, issn = {0304-3835}, title = {Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids}, keyword = {5-Fluorouracil, 5-Fluorouridine, Octreotide, NMR spectroscopy, Multicell spheroids, Colon adenocarcinoma HT-29 cells} }
@article{article, year = {1994}, pages = {41-51}, keywords = {5-Fluorouracil, 5-Fluorouridine, Octreotide, NMR spectroscopy, Multicell spheroids, Colon adenocarcinoma HT-29 cells}, journal = {Cancer Letters}, volume = {86}, number = {1}, issn = {0304-3835}, title = {Somatostin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids}, keyword = {5-Fluorouracil, 5-Fluorouridine, Octreotide, NMR spectroscopy, Multicell spheroids, Colon adenocarcinoma HT-29 cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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