engleski

Soluble Adhesion Molecules In Acute Ischemic Stroke

Aim: We try to explore the potential association of plasma levels of soluble (s) intercellular and vascular cellular adhesion molecules-I (sICAM-1 and sVCAM-1), sE-selectin and sL-selectin in patients with acute ischemic stroke. Methods: We prospectively enrolled 67 subjects with acute ischemic stroke, and 76 consecutive healthy individuals. Serum concentrations were determined by means of quantitative sandwich enzyme immunoassay. Results: Mean levels of sICAM-1 (p<0.001), sVCAM-1 (p<0.034) and sE-selectin (p<0.002) were higher in patients than in controls, whereas sL-selectin was lower in patients (p=0.043). The levels of soluble adhesion molecules were independent of age and sex except for sL-selectin, which was inversely correlated with age (r~.260, p=0.034) and higher in women (p=0.006) and diabetics (n=14 ; p=0.004). Serum levels did not differ significantly with respect to carotid atherosclerotic disease, smoking status, hypertension or hypercholesterolemia. As well as correlating with each other, concentrations of soluble adhesion molecules in patients eorrelated with traditional biochemical markers of inflammation: total leukocyte count, erythrocyte sedimentation rate (ESR) and C-reactive protein level. Concentrations of sTCAM-1 and high-density lipoprotein-cholesterol and ESR were identified as significant independent predictors/indicators of acute ischemic stroke. Conclusions: Acute ischemic stroke is associated with elevated plasma levels of sICAM-1, sVCAM-I and sE-selectin. Decreased levels of sL-selectin are associated with acute stroke. The observed changes in serum concentrations of adhesion molecules indicate inflammatory processes occurring during acute cerebral ischemia.

Adhesion molecules; stroke; etiology

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