engleski

Atrial stretch is the principal determinant controlling the acute release of atrial natriuretic peptide in the liver cirrhosis

The aim of the study was to assess the influence of the paracentesis, bed rest 24 h before and after the procedure, and volume replacement on the acute release of atrial natriuretic peptide (ANP) in patients (pts) with tense ascites in Child-Pugh C liver cirrhosis. Forty pts were randomly allocated into 4 groups: 30 pts were treated with paracentesis of 6 L of ascites paralleled by plasma volume expansion with low sodium albumin, fresh frozen plasma, or solution of synthetic gelatine, and bed rest for 24 h before and after the procedure, and compared with 10 pts treated with paracentesis without plasma volume expansion and no bed rest. Cardiac release of ANP in response to volume expansion was not impaired in pts with Child-Pugh C liver cirrhosis and tense ascites. The main mechanism stimulating the acute release of ANP was atrial stretching, induced with volume expansion and was proportional to its amount.

liver cirrhosis; therapy; ascites; therapy; paracentesis; volume replacement; atrial strech; atrial natriuretic peptide

nije evidentirano