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Pregled bibliografske jedinice broj: 271877

Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism


Pašalić, Daria; Ferenčak, Goran; Gršković, Branka; Stavljenić-Rukavina Ana
Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism // Periodicum Biologorum, 108 (2006), 5; 553-562 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism

Autori
Pašalić, Daria ; Ferenčak, Goran ; Gršković, Branka ; Stavljenić-Rukavina Ana

Izvornik
Periodicum Biologorum (0031-5362) 108 (2006), 5; 553-562

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
atherosclerosis; coronary artery disease; genes; lipoproteins; metabolism

Sažetak
Atherosclerosis is an inflammatory disease resulting from interaction between environment and genetic make up. Familial lipoprotein disorders are frequent in subjects with premature coronary artery disease (CAD). The majority of lipoprotein disorders result from a combination of polygenic predisposition and poor lifestyle habits. Many different proteins are involved in lipoprotein metabolism, which includes different enzymes, enzyme inhibitors and activators, cell receptors, ligands that bind to the cell receptors, and proteins involved in lipoprotein structure. We present an overview of some common genetic factors that influence lipoprotein metabolism and the involvement of the most frequent polymorphisms in the development of CAD. These include gene variants of apolipoproteins A-IV, A-V, C-III, B-100 and E, LDL-receptor, apolipoprotein(a), lipoprotein lipase, hepatic lipase, cholesteryl-ester transfer protein, paraoxonase and peroxisome proliferator-activated receptor. Despite of the numerous association studies, meta-analyses and scientific advances the ability to detect and prevent premature CAD remains limited. As the number of reproducible results increases, gene markers will become a useful tool of determining the CAD risk in clinical medicine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
0108247

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Pašalić, Daria; Ferenčak, Goran; Gršković, Branka; Stavljenić-Rukavina Ana
Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism // Periodicum Biologorum, 108 (2006), 5; 553-562 (međunarodna recenzija, pregledni rad, znanstveni)
Pašalić, D., Ferenčak, G., Gršković, B. & Stavljenić-Rukavina Ana (2006) Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism. Periodicum Biologorum, 108 (5), 553-562.
@article{article, year = {2006}, pages = {553-562}, keywords = {atherosclerosis, coronary artery disease, genes, lipoproteins, metabolism}, journal = {Periodicum Biologorum}, volume = {108}, number = {5}, issn = {0031-5362}, title = {Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism}, keyword = {atherosclerosis, coronary artery disease, genes, lipoproteins, metabolism} }
@article{article, year = {2006}, pages = {553-562}, keywords = {atherosclerosis, coronary artery disease, genes, lipoproteins, metabolism}, journal = {Periodicum Biologorum}, volume = {108}, number = {5}, issn = {0031-5362}, title = {Gene candidates for atherosclerosis: genes involved in lipoprotein metabolism}, keyword = {atherosclerosis, coronary artery disease, genes, lipoproteins, metabolism} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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