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Pregled bibliografske jedinice broj: 271847

Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy


Čikeš Čulić, Vedrana; Kurir Tičinović, Tina; Radić, S.; Zemunik, Tatijana; Mesarić, M.; Markotić, Anita
Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy // Abstracts of the 31st FEBS Congress "Molecules in Health and Disease" ; u: The FEBS Journal 273 (2006) (S1) ; PP-691 / Perham, Richard (ur.).
Oxford: Blackwell Publishing Ltd, 2006. str. 264-264 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Exposure to hyperbaric pressure alters ganglioside expression in rat liver following partial hepatectomy

Autori
Čikeš Čulić, Vedrana ; Kurir Tičinović, Tina ; Radić, S. ; Zemunik, Tatijana ; Mesarić, M. ; Markotić, Anita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 31st FEBS Congress "Molecules in Health and Disease" ; u: The FEBS Journal 273 (2006) (S1) ; PP-691 / Perham, Richard - Oxford : Blackwell Publishing Ltd, 2006, 264-264

Skup
31st FEBS Congress "Molecules in Health and Disease"

Mjesto i datum
Istanbul, Turska, 24.-29.06.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hyperbaric oxygenation; liver regeneration; gangliosides

Sažetak
Remnant liver after partial hepatectomy (PH) demands an increased amount of oxygen to restore hepatic energy. Modulation of the ganglioside content of hepatocyte plasma membrane could provide a mean for upregulating cellular responsiveness to a variety of factors. Rat liver gangliosides were analysed by high performance thin layer chromatography (HPTLC) followed with immunostaining 54 h after PH. Non-operated and three different groups of operated rats were studied according to the hausing conditions before or after operation: recovering under normal ambient conditions after operation (1), treating with hyperbaric pressure before operation and recovering under normal ambient conditions (2 or preHB), and recovering under hyperbaric pressure after operation (3 or postHB). Liver of preHB group showed the highest expression of ganglioside GD1a, a marker of a peculiar transition phase of liver regeneration. Same animals showed enhanced expression of the several gangliosides: GM2, GM1a, GD1b, GT1b, Gal-NAcGM1b, nLc4, nLc6 and nLc8. Since galactosyl- and N-acetylgalactosaminyltransferase catalyse final step of synthesis of GM2, GM1a, GD1b, Gal-NAcGM1b, nLc4, nLc6, and nLc8, our results point at possible role of galactosyl- and N-acetylgalactosaminyltransferase in regulation of the liver growth after PH.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0216013

Ustanove
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE