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Pregled bibliografske jedinice broj: 270905

Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations


Rajić, Zrinka; Zorc, Branka; Raić-Malić, Silvana; Ester, Katja; Kralj, Marijeta; Pavelić, Krešimir; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations // Molecules, 11 (2006), 11; 837-848 doi:10.3390/11110837 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 270905 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations

Autori
Rajić, Zrinka ; Zorc, Branka ; Raić-Malić, Silvana ; Ester, Katja ; Kralj, Marijeta ; Pavelić, Krešimir ; Balzarini, Jan ; De Clercq, Erik ; Mintas, Mladen

Izvornik
Molecules (1420-3049) 11 (2006), 11; 837-848

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hydantoin ; L- and D-amino acids ; antiviral activity ; antitumoral activity

Sažetak
3, 5-Disubstituted hydantoin (1, 3-imidazolidinedione) derivatives 5a-h were prepared by base induced cyclization of the corresponding N-(1-benzotriazolecarbonyl)-L- and D-amino acid amides 4a-h. Compounds 5a-h were evaluated for their cytostatic and antiviral activities. Among all the compounds evaluated, 3-benzhydryl-5-isopropyl hydantoin (5a) showed a weak but selective inhibitory effect against vaccinia virus (EC50 = 16  g/mL ; selectivity index: 25). 3-Cyclohexyl-5-phenyl hydantoin (5g) showed inhibitory activity against cervical carcinoma (HeLa, IC50 = 5.4  M) and breast carcinoma (MCF-7, IC50 = 2  M), but also cytotoxic effects towards human normal fibroblasts (WI 38). On the contrary, the 3-benzhydryl-5-phenyl substituted hydantoin derivative 5h showed moderate inhibitory activity towards HeLa, MCF-7, pancreatic carcinoma (MiaPaCa-2), lung carcinoma (H 460) and colon carcinoma (SW 620) (IC50 = 20 23  M), but no effect on WI 38.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
0098093 - 0098093 (, )
0125003 - 0125003 (, )
0006543 - 0006543 (, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Citiraj ovu publikaciju

Rajić, Zrinka; Zorc, Branka; Raić-Malić, Silvana; Ester, Katja; Kralj, Marijeta; Pavelić, Krešimir; Balzarini, Jan; De Clercq, Erik; Mintas, Mladen
Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations // Molecules, 11 (2006), 11; 837-848 doi:10.3390/11110837 (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Zorc, B., Raić-Malić, S., Ester, K., Kralj, M., Pavelić, K., Balzarini, J., De Clercq, E. & Mintas, M. (2006) Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations. Molecules, 11 (11), 837-848 doi:10.3390/11110837.
@article{article, year = {2006}, pages = {837-848}, DOI = {10.3390/11110837}, keywords = {Hydantoin, L- and D-amino acids, antiviral activity, antitumoral activity}, journal = {Molecules}, doi = {10.3390/11110837}, volume = {11}, number = {11}, issn = {1420-3049}, title = {Hydantoin derivatives of L- and D-amino acids: synthesis, antiviral and antitumoral activity evaluations}, keyword = {Hydantoin, L- and D-amino acids, antiviral activity, antitumoral activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts


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