engleski

INTESTINAL IMMUNE RESPONSE OF PIGS IMMUNIZED WITH F4AC+ NONENTEROTOXIGENIC ESCHERICHIA COLI STRAIN

The protection from porcine enteric colibacillosis is related to either the passive transfer of lactogenic immunity or the induction of mucosal immunity to prevent the development of neonatal or postweaning diarrhea, respectively. Protection against microbial antigens such as enterotoxigenic Escherichia coli (ETEC) strains at the mucosal surfaces of intestine is achieved by a combination of specific and non-specific defense mechanisms mediated by immune cells from the gut-associated lymphoid tissues (GALT). The normal route by which bacterial antigens are taken up by the GALT is via the epithelial surface of the small intestine. In this study the immunogenicity of genetical engineered F4ac+ non-ETEC strain, used as the source of replicating antigen in weaned pigs, was evaluated by qualitative and quantitative parameters of the intestinal immunity. Orogastric immunization of pigs with F4ac+ non-ETEC strain induced increase of the relative proportions of SWC8+ lymphoid and SWC3+ myeloid cells in the ileal Peyer's patches.The function ability of lymphoid and myeloid cells was also increased determined by in vitro responsiveness to F4 antigen.The results imply the achievement of solid immunogenicity of live oral vaccine against postweaning colibacillosis.

F4ac+ non-ETEC; pig; intestinal immune response

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