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Pregled bibliografske jedinice broj: 269162

Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content


Cvek, Josipa; Zubčić, Snježana; Vitali, Dubravka; Vedrina-Dragojević, Irena; Tomić, Siniša; Medić-Šarić, Marica
Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content // Planta Medica: 54th Annual Congress on Medicinal Plant Research / Hamburger, Matthias (ur.).
Stuttgart, Njemačka: Georg Thieme Verlag KG Stuttgart - New York, 2006. str. 1063-1064 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 269162 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content

Autori
Cvek, Josipa ; Zubčić, Snježana ; Vitali, Dubravka ; Vedrina-Dragojević, Irena ; Tomić, Siniša ; Medić-Šarić, Marica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Planta Medica: 54th Annual Congress on Medicinal Plant Research / Hamburger, Matthias - Stuttgart, Njemačka : Georg Thieme Verlag KG Stuttgart - New York, 2006, 1063-1064

Skup
54th Annual Congress on Medicinal Plant Research

Mjesto i datum
Helsinki, Finska, 29.08.-02.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
propolis ; wax content

Sažetak
The increasing use of propolis preparations nowdays requires setting of clear criteria for their quality control. For that purpose, ten tinctures of propolis samples from different Croatian regions were subjected to analysis of general pharmacopoeial parameters wich are fundamental for the creation of quality specification. These are relative density (determined using instrument Mettler Toledo DE40 Density Meter), dry residue of extract (determined according to Ph. Eur. 5.0 method), and content of ethanol and its possible impurities - methanol and isopropanol (developed and validated gas chromatography method for their simultaneous analysis was applied). Additionally, by the method of Woisky and Salatino we determined the content of waxes as the main inactive constituents in order to determine the level of their migration from crude propolis samples to the prepared tinctures (extraction solvent: 80% V/V ethanol ; drug - preparation ratio = 1:10) (1). Relative density values increased along with the increase of dry residue of extract (e.g. the lowest values were determined in propolis tincture from South Dalmatian Islands: d20 = 0.8688, RSD(n = 2) = 0.42% and dry residue = 4.40% w/w, RSD(n = 2) = 0.80% while the highest values were obtained for propolis tincture from central Croatia: d20 = 0.8841, RSD(n = 2) = 0.01% and dry residue = 7.62% w/w, RSD(n = 2) = 0.28%). Investigated validation parameters for GC method satisfied the acceptance criteria (correlation coefficient more than 0.999 ; precision: RSD(n = 21) = 0.60% ; average recovery(n = 21): 99.08 % ; DL = 0.001% for methanol and 0.002% for isopropanol ; QL = 0.003% for methanol and 0.006% for isopropanol). Ethanol content was in range from 73.98 to 77.74% V/V (RSD(n = 3) = 0.06– 2.43%) which is in accordance with USP 29 requirement for alcohol content in herbal extracts (90– 110% of declared amount). Contents of methanol and isopropanol were below detection limits. Presence of waxes was not observed in propolis tinctures indicating the suitability of applied extraction method. References: 1. Woiski, R. G., Salatino, A. (1998) J. Apic. Res. 37(2):99- 105.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
0006541

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb


Citiraj ovu publikaciju

Cvek, Josipa; Zubčić, Snježana; Vitali, Dubravka; Vedrina-Dragojević, Irena; Tomić, Siniša; Medić-Šarić, Marica
Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content // Planta Medica: 54th Annual Congress on Medicinal Plant Research / Hamburger, Matthias (ur.).
Stuttgart, Njemačka: Georg Thieme Verlag KG Stuttgart - New York, 2006. str. 1063-1064 (poster, međunarodna recenzija, sažetak, znanstveni)
Cvek, J., Zubčić, S., Vitali, D., Vedrina-Dragojević, I., Tomić, S. & Medić-Šarić, M. (2006) Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content. U: Hamburger, M. (ur.)Planta Medica: 54th Annual Congress on Medicinal Plant Research.
@article{article, editor = {Hamburger, M.}, year = {2006}, pages = {1063-1064}, keywords = {propolis, wax content}, title = {Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content}, keyword = {propolis, wax content}, publisher = {Georg Thieme Verlag KG Stuttgart - New York}, publisherplace = {Helsinki, Finska} }
@article{article, editor = {Hamburger, M.}, year = {2006}, pages = {1063-1064}, keywords = {propolis, wax content}, title = {Quality caracterisation of propolis tinctures by pharmacopoeial parameters and wax content}, keyword = {propolis, wax content}, publisher = {Georg Thieme Verlag KG Stuttgart - New York}, publisherplace = {Helsinki, Finska} }




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