engleski

Retraction clefting and prostatic intraepithelial neoplasia in needle core biopsies

In comparison to normal glands retraction clefting is more common and prominent around neoplastic acini and therefore represents an additional criterion for the diagnosis of prostatic adenocarcinoma. Prostatic intraepithelial neoplasia (PIN) composed of abnormal proliferation within the prostate ducts, ductules, and large acini, premalignant foci of cellular dysplasia and carcinoma in situ without stromal invasion is the most likely precursor of prostatic adenocarcinoma. However, in the literature, we were not able to find data on the relationship between clefts and prostatic intraepithelial neoplasia. Purpose of the study: To determine the presence and extent of retraction clefting in glands with prostatic intraepithelial neoplasia (PIN) in needle core biopsies. We analyzed needle core biopsies from 35 consecutive biopsies of patients with PIN diagnosed at the Department of Pathology, Sestre milosrdnice Universty Hospital. Specimens were fixed in 10% buffered formaldehyde, embedded in paraffin, cut at 4 μ m and routinely stained with hematoxylin and eosin. Glands with PIN were analyzed on high power field (400x) and classified in three groups: group I (no clefting), group II (clefting in up to 50% of gland circumference) and group III (clefts in more than 50% of gland circumference). Normal glands within the same biopsy served as a control. The age of the patients ranged from 53 to 84 years (median 67.8 years), with the PSA value from 4.2 to 121 ng/ml. In glands with PIN, clefts in more than 50% of gland circumference were not found. There were 8 PIN (22.8%) cases with clefting in less than 50% of circumference (group II) and 27 (78.2%) cases with no clefting. Our results showing the lack of retraction clefting in PIN cases suggest the influence of stromal reaction in the development of clefts around neoplastic acini of prostatic adenocarcinoma and therefore clefting should not be considered as an aid in the differential diagnosis of PIN.

retraction clefting prostatic; intraepithelial neoplasia; needle core biopsies

Rad je kao poster prezentiran na skupu 20th ESP Congress, održanom od 0.3-08.09.2005., Aix-les-Bains, Francuska.