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Pregled bibliografske jedinice broj: 267641

Effect of Creatine on the Pancreatic ß-Cell


Ročić, Boris; Vučić Lovrenčić, Marijana; Poje, Mirko; Ashcroft, Stephen
Effect of Creatine on the Pancreatic ß-Cell // Experimental and Clinical Endocrinology & Diabetes, 115 (2007), 1; 29-32 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 267641 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effect of Creatine on the Pancreatic ß-Cell

Autori
Ročić, Boris ; Vučić Lovrenčić, Marijana ; Poje, Mirko ; Ashcroft, Stephen

Izvornik
Experimental and Clinical Endocrinology & Diabetes (0947-7349) 115 (2007), 1; 29-32

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
creatine; ATP; insulin secretion; MIN-6 ß-cells

Sažetak
We report on the stimulatory effect of creatine on insulin secretion and ATP concentration from MIN-6 ß-cells. The addition of creatine (5 mM) to MIN-6 cells in the presence of glucose (1-10 mM) elicited a significant (p<0.001) increase in insulin secretion, but no effect was demonstrated in the absence of glucose. The lack of effect of creatine in the absence of glucose suggests that creatine may act as a potentiator of insulin secretion rather than as an initiator. The potentiatory effect of creatine is specific for glucose since no effect was found in the presence of other known initiators of insulin secretio (K+, 2-ketoisocaproic acid, and tolbutamide). Cellular ATP content was markedly increased by glucose (1-15 mM). Creatine (5 and 10 mM) further increased the ATP level at all glucose concentrations, and the effect was observed even in the absence of glucose. The results from this study demonstrate the ability of creatine to increase insulin secretion only in the presence of glucose, while its effect on increased cellular ATP was independent on the presence of glucose. The mechanism whereby creatine potentiates insulin release is yet to be investigated. However, our data suggest possible unique interactions between creatine and the glucose-dependent insulin secretory pathway.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0119613
045001
045-1191348-0139 - Biomolekule guanidinskog tipa u šećernoj bolesti (Vučić Lovrenčić, Marijana, MZOS ) ( POIROT)

Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju:

Ročić, Boris; Vučić Lovrenčić, Marijana; Poje, Mirko; Ashcroft, Stephen
Effect of Creatine on the Pancreatic ß-Cell // Experimental and Clinical Endocrinology & Diabetes, 115 (2007), 1; 29-32 (međunarodna recenzija, članak, znanstveni)
Ročić, B., Vučić Lovrenčić, M., Poje, M. & Ashcroft, S. (2007) Effect of Creatine on the Pancreatic ß-Cell. Experimental and Clinical Endocrinology & Diabetes, 115 (1), 29-32.
@article{article, year = {2007}, pages = {29-32}, keywords = {creatine, ATP, insulin secretion, MIN-6 ß-cells}, journal = {Experimental and Clinical Endocrinology and Diabetes}, volume = {115}, number = {1}, issn = {0947-7349}, title = {Effect of Creatine on the Pancreatic ß-Cell}, keyword = {creatine, ATP, insulin secretion, MIN-6 ß-cells} }
@article{article, year = {2007}, pages = {29-32}, keywords = {creatine, ATP, insulin secretion, MIN-6 ß-cells}, journal = {Experimental and Clinical Endocrinology and Diabetes}, volume = {115}, number = {1}, issn = {0947-7349}, title = {Effect of Creatine on the Pancreatic ß-Cell}, keyword = {creatine, ATP, insulin secretion, MIN-6 ß-cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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