engleski

Salivary interleukin 6 and tumour necrosis factor alpha in periodontal disease

Periodontal disease is a chronic inflammatory disease related closely to the bacteria, host responses and genetics. However, its clear ethiopathogenesis still remains unclear. Cytokines have been known to have tremendous influence on oral diseases as well as periodontal disease. The aim of this study was to evaluate salivary interleukin 6 and tumour necrosis factor a levels in patients with periodontal disease as it is known that cytokines are the key mediators of the host response to antigens. Study group consisted of 27 participants (18 males and 9 females), age range 28– 62 yrs, mean 37.2 yrs. The control group consisted of 37 controls, age range 27– 65 yrs ; mean 39.3 yrs. Enzyme-linked immunoassay was used to determine the concentration of IL-6 and TNF-a in the whole saliva. Statistical analysis was done by use of Student t test and values below 0.05 were considered as significant. Levels of salivary IL-6 were significantly increased in patients with periodontal disease when compared to the control group (P = 0.041). Levels of salivary TNF-a did not differ between patients and controls (P = 0.88). We might conclude that salivary IL-6 plays more important role in periodontal disease than TNF-a and their action is not synergistic as it was previously taught.

periodontal disease; il-6; TNFalfa

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