engleski

Immunogenetic profile of late onset psoriasis

Psoriasis vulgaris has been subclassified according to age of onset. Early-onset psoriasis (also referred to as type I) has the onset before age 40, with a peak onset at age 16-22, and accounts for 70% of all psoriatics. Late-onset psoriasis (LOP), also termed type II psoriasis, shows the onset at or after age 40, with a peak onset at age 57-60. Although these forms of psoriasis cannot be distinguished on clinical and histopathological grounds, a distinct pattern of HLA associations has been reported. So, in early-onset psoriasis which also displays a strong family history, strong associations with class I alleles and specifically HLA-Cw6 have been observed. The aims of the study were to identify the immunogenetic features of late-onset psoriasis as a clinical entity, and to compare LOP and psoriasis vulgaris (PV) according to their immunogenetic profiles. Twenty-eight LOP patients were typed for HLA class I and class II.Control group consisted of 190 unrelated healthy blood donors and patients with psoriasis type I.In psoriasis type I, there was a significantly higher frequency of HLA alleles B13 (OR=8.89), B 57 (OR=9.34), Cw*06 (OR=12.78), DQB1*0701 (OR=9.70), DQA1*0201 (OR=4.92) and DQB1* 0303 (OR=53.89). In psoriasis type II, the frequency of HLA alleles did not differ significantly from that in control group.

late-onse psoriasis; immunogenetic features

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