engleski

Deep venous thrombosis-a clinical epidemiology overview

Aim. To determine clinical findings, risk factors of deep venous thrombosis (DVT) and outcomes in our group of patients. Methods. A retrospective review of 203 patients treated for DVT at the intensive care unit of the Sestre milosrdnice University hospital in Zagreb over 8-year period. Eighty-five (41.9%) were male and 118 (58.1%) were female, mean age 58. Epidemiological analysis was performed according to sex, age, previous DVT, outcomes and risk factors (obesity, cancer, recent surgery and immobilisation, acquired or familial thrombophilia). Results. Seven (2.3%) patients died, six of pulmonary embolism and one of acute myocardial infarction. Personal history was negative in 171 (84%). Obesity was present in 54 (26.6%), bed rest in 48 (23.6%), estrogen consumption in 16 (7.9%) patients, malignant neoplastic disease in 38 (18.7%) patients, the most frequent was brest cancer (3.4%) in the group of middle aged women. Factors of thrombophilia have been performed in 19 patients. Of these three factors observed together the most frequent were MTHRF+PAI-1 heterozygous alterations in 5 (26.3%) patients and FV heterozygous alterations in 3 (15.8%) patients. Conclusion. Individual risk stratification is needed in order to modify exposures, and target primary and secondary prophylaxis to the person who would benefit most.

deep venous thrombosis-therapy; epidemiology; outcome

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